Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes, but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemo preventive and therapeutic effects against various ailments. Resveratrol’s role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed. This review covers the literature that deals with the anti-cancer mechanism of resveratrol with special reference to antioxidant potential. Furthermore, this article summarizes the literature pertaining to resveratrol as an anti-cancer agent.
Crit Rev Food Sci Nutri, 58 (9), 1428-1447 2018 Jun 13
Resveratrol as an Anti-Cancer Agent: A Review Abdur Rauf 1, Muhammad Imran 2, Masood Sadiq Butt 3, Muhammad Nadeem 4, Dennis G Peters 5, Mohammad S Mubarak 6
Besides chemo preventive effects, resveratrol appears to exhibit therapeutic effects against cancer. Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer.
Anticancer Res , 24 (5A), 2783-840 Sep-Oct 2004 Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies