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LAETRILE/VIT B17 – AMYGDALIN FROM APRICOT KERNELS INDUCES APOPTOSIS AND CAUSES CELL CYCLE ARREST IN CANCER CELLS: AN UPDATED REVIEW

 doi: 10.2174/1871520618666180105161136.

Amygdalin from Apricot Kernels Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review

Mohammad Saleem 1, Jawaria Asif 2, Muhammad Asif 2, Uzma Saleem 2

Abstract

Background: Amygdalin is a cyanogenic glycoside which is described as a naturally occurring anticancer agent. Current review highlights apoptosis-inducing attributes of amygdalin towards different cancers and its potential application as an anti-cancer agent in cancer therapy.

Method: Data about amygdalin was retrieved from all major scientific databases i.e., PubMed, ScienceDirect, Google Scholar, Scopus and Medline by using combination of keywords like amygdalin, apoptosis, laetrile, vitamin B- 17, pro-apoptotic proteins, anti-apoptotic proteins, hydrogen cyanide, mechanism of action of amygdalin and amygdalin therapy on humans. However, no specific time frame was followed for collection of data.

Results: Data collected from already published articles revealed that apoptosis is a central process activated by amygdalin in cancer cells. It is suggested to stimulate apoptotic process by upregulating expression of Bax (proapoptotic protein) and caspase-3 and downregulating expression of Bcl-2 (anti-apoptotic protein). It also promotes arrest of cell cycle in G0/G1 phase and decrease number of cells entering S and G2/M phases. Thus, it is proposed to enhance deceleration of cell cycle by blocking cell proliferation and growth.

Conclusion: The current review epitomizes published information and provides complete interpretations about all known anti-cancer mechanisms of amygdalin, possible role of naturally occurring amygdalin in fight against cancer and mistaken belief about cyanide toxicity causing potential of amygdalin. However, well-planned clinical trials are still needed to be conducted to prove effectiveness of this substance in vivo and to get approval for human use.

Anticancer Agents Med Chem 2018;18(12):1650-1655.

Keywords: Amygdalin; Bax; Bcl-2; apoptosis; cancer; caspase-3..

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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  • Home
  • Cam Conference 2024
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    • Living Beyond Breast Cancer conference
    • Alternative Cancer Therapies >
      • laetrile-vit-b17-amygdalin-from-apricot-kernels-induces-apoptosis-and-causes-cell-cycle-arrest-in-cancer-cells-an-updated-review
    • Handouts
  • Vlog
    • 2018 AAPR Conference
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