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Epidemiology Lifetime physical activity and the risk of renal cell cancer Alessandra Tavani 1 *, Antonella Zucchetto 2, Luigino Dal Maso 2, Maurizio Montella 3, Valerio Ramazzotti 4, Renato Talamini 2, Silvia Franceschi 5, Carlo La Vecchia 1 6 1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
2Unitá di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy 3Servizio di Epidemiologia, Istituto Tumori Fondazione Pascale, Naples, Italy 4Servizio Integrato di Epidemiologia e Sistemi Informativi, Istituto Nazionale Tumori Regina Elena, Rome, Italy 5International Agency for Research on Cancer, Lyon, France 6Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy email: Alessandra Tavani ([email protected]) *Correspondence to Alessandra Tavani, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy Fax: +39-02-3900-1916. Funded by: Italian Association for Cancer Research Italian League against Cancer Italian Ministry of Education; Grant Number: PRIN 2005 Abstract The relation between lifelong physical activity at work and during leisure-time and the risk of renal cell cancer (RCC) was analyzed in a case-control study conducted in Italy between 1992 and 2004. Cases were 767 subjects with incident, histologically confirmed RCC, and controls were 1,534 patients hospitalized for acute nonneoplastic conditions. Odds ratios (OR) and 95% confidence intervals (CI) for RCC were computed by multiple logistic regression models, conditioned on study center, sex and age, and adjusted for main covariates. Compared to the lowest level of occupational physical activity, the multivariate OR of RCC for the highest level were 0.65 (95% CI 0.49-0.87) at age 12 years, 0.67 (95% CI 0.53-0.84) at age 15-19, 0.74 (95% CI 0.59-0.93) at age 30-39 and 0.71 (95% CI 0.55-0.92) at age 50-59 years, with significant inverse trends in risk. The inverse association was consistent in strata of sex, age at diagnosis, body mass index, smoking habit and alcohol drinking. No significant association was found for leisure-time physical activity. The inverse association between occupational physical activity and RCC risk, if real, may be related to the effects of insulin-like growth factors, or lipid peroxidation and about 9% of cases of RCC in Italy could be avoided by increasing physical activity. However the inverse association might involve confounding by indirect mechanisms, such as body composition or other social class correlates. International Journal of Cancer Volume 120, Issue 9 , Pages 1977 – 1980
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