Liver Protection w/ Amoora rohituka
Excerpt from: Hepatoprotective effect of Amoora rohituka
Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka was studied in rats with hepatic injury induced by carbon tetrachloride.
Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A.rohituka (50 mg/kg/day) was given orally for the same period.
The rats were sacrified 24 h after the last CC 14 challenge. Carbon tetrachloride induced elevation of alkaline phosphate (ALP), glutamate pyruvate transaminase (GPT) , alanine aminotransferase (ALAT), glutamate oxaloacetate transamainase (GOT) aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concenteration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension.
Changes in the histological architecture of the liver produced by CC14 were also protected by the administration of A rohituka suspension.
M.K. Gole, S. Dasgupta, R.K. Sur & J. Ghosal
Department of Physiology
University College of Science and Technology
92 APC Road
Calcutta 700 009 West Bengal India
International Journal of Pharmacognosy Volume 35, 1997 – Issue 5
Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka was studied in rats with hepatic injury induced by carbon tetrachloride.
Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A.rohituka (50 mg/kg/day) was given orally for the same period.
The rats were sacrified 24 h after the last CC 14 challenge. Carbon tetrachloride induced elevation of alkaline phosphate (ALP), glutamate pyruvate transaminase (GPT) , alanine aminotransferase (ALAT), glutamate oxaloacetate transamainase (GOT) aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concenteration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension.
Changes in the histological architecture of the liver produced by CC14 were also protected by the administration of A rohituka suspension.
M.K. Gole, S. Dasgupta, R.K. Sur & J. Ghosal
Department of Physiology
University College of Science and Technology
92 APC Road
Calcutta 700 009 West Bengal India
International Journal of Pharmacognosy Volume 35, 1997 – Issue 5