CAM Conference

Although the following study was done in rats, and is ostensibly about mutations in the colon, it has much broader implications. We have all heard that sugar is a no no for people with cancer. This study gives us more information, see the conclusion.

A sucrose-rich diet induces mutations in the rat colon.

Dragsted LO, Daneshvar B, Vogel U, Autrup HN, Wallin H, Risom L, Moller P, Molck AM, Hansen M, Poulsen HE, Loft S

Institute of Food Safety and Nutrition, Division of Biochemical and Molecular Toxicology, The Danish Veterinary and Food Administration, DK-2860 Soborg, Denmark.

A sucrose-rich diet has repeatedly been observed to have cocarcinogenic actions in the colon and liver of rats and to increase the number of aberrant crypt foci in rat colon.

To investigate whether sucrose-rich diets might directly increase the genotoxic response in the rat colon or liver, we have added sucrose to the diet of Big Blue rats, a strain of Fischer rats carrying 40 copies of the lambda-phage on chromosome 4.

Dietary sucrose was provided to the rats for 3 weeks at four dose levels including the background level in the purified diet [3.4% (control), 6.9%, 13.8%, or 34.5%] without affecting the overall energy and carbohydrate intake. We observed a dose-dependent increase in the mutation frequency at the cII site in the colonic mucosa with increased sucrose levels, reaching a 129% increase at the highest dose level.

This would indicate a direct or indirect genotoxic effect of a sucrose-rich diet. No significant increase in mutations was observed in the liver. To seek an explanation for this finding, a variety of parameters were examined representing different mechanisms, including increased oxidative stress, changes in oxidative defense, effects on DNA repair, or changes in the background levels of DNA adducts.

Sucrose did not increase the number of DNA strand breaks or oxidized bases assessed as endonuclease III-sensitive sites or 8-oxodeoxyguanosine in colon or liver. DNA repair capacity as determined by expression of the rERCC1 or rOGG1 genes was not increased in colon or liver, but the background level of DNA adducts (I-compounds) as determined by (32)P postlabeling was significantly decreased in colon.

This decrease in colon I-compounds correlated inversely with both mutation frequency and ERCC1 DNA repair gene expression. Dietary sucrose did not change liver apoptosis or cell turnover as determined by the terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end labeling assay and proliferating cell nuclear antigen.

An increase in liver ascorbate was also observed, whereas oxidative damage was not observed in proteins or lipids in liver cytosol or in blood plasma. We conclude that a sucrose-rich diet directly or indirectly increases the mutation frequency in rat colon in a dose-dependent manner and concomitantly decreases the level of background DNA adducts, without a direct effect on the expression of major DNA repair enzyme systems.

We also conclude that an oxidative mechanism for this effect of sucrose is unlikely.

This is the first demonstration of a genotoxic action of increased dietary sucrose in vivo. Both sucrose intake and colon cancer rates are high in the Western world, and our present results call for an examination of a possible direct relationship between the two.

Cancer Res 2002 Aug 1;62(15):4339-45

Please find other studies of interest in the “Vitamins/Dietary Supplements” section of “Relevant Studies”.

Articles on Bladder cancer,
some on detection methods

Survivin for Diagnosis Bladder Cancer
Microsatellite Analysis More Sensitive
Survival Bk & Wh Bladder Ca Patients
Vitamins and Bladder Cancer
Glutathione Chemoprotective: Bladder Ca
Long-term Bladder Function After Treatment
Dietary Isothiocyanates Inhibit Growth Bladder Ca Cells
Antrodia camphorata extract inhibits absolute migration capability invasive bladder ca cells
Dogs ‘Smell’ Bladder Cancer
Bladder Cancer Patient Organizations
Selenium and bladder cancer risk

Articles, studies, etc.

Brain Cancer Organizations
Synthesized Scorpion Venom & Brain Ca Drug
In Vitro Sensitivity Increased Survival:Glioblastoma
Antitumor Effects:Cannabidiol & Brain Tumors
Tumor Control/Toxicity 1 Yr After RTx Brain Mets
HhAntag Nontoxic Therapy for Medulloblastoma
Extrnl Pneumatic Compression Device/Compress Stockings
Resvertarol Induces Cell Death Human Glioma Cells
Autologous Brain Tumor Vaccine
Antineoplastons: Dr. S. Burzynski
Financial Impact of Brain Tumors
Methotrexate May Cure up to 20% w/ Rare Brain Tumor
Less Intense Treatment for Advanced Neuroblastoma Achieves High Survival Rates

Intro-What is Cachexia
Hypercaloric Feeding-Omega-3 Helpful
Branched-chain Amino Acids
Eicosapentanoic Acid -Fish Oil
Other agents including Hydrazine Sulfate
Nutrititional, Psychological & Behavioral Therapies
Complete References for Main Article ABOVE
Cachexia in Cancer Patients
Caxechia & Oxidative Stress
Celecoxib, Medroxyprogesterone, Dietary :Lung Ca
Cancer Patients, Nutrition, Wasting,
Hydrazine Sulfate Influence on Nutritional Status/Survival NSCLC
Yo-Yo Dieting Weakens Immune System
Pathogenesis & Treatment: Cachexia in Aged Pts
Cachexia, Oxidative Stress, Antioxidants, Pharmaco-nutrition Ova

Marine Phytoplankton
Small, asymptomatic neuroendocrine pancreatic tumours
Carcinoid Organizations

Reduction of risk observed in meta-analysis

Other colon cancer issues

Colorectal Cancer Groups
Chewing Gum Relieves Ileus After Colorectal Surgery
Diet Appears to Influence Colon Cancer OUTCOMES
Olive Oil & Colon Cancer
Sentinel Node for Colon Cancer
Dietary Factors in Human Colorectal Cancer
Implementation of a Healthy Diet (over 4 Years)
Dietary Indoles/Isothiocyanates Useful for Colon Ca
Milk Intake, Insulin-like growth Factor and Risk of Colon Ca/Men
Carageenan and Colon Cancer
Trans-Fatty Acids & Colon Ca
Dietary Fiber & Carcinogenesis
Grape Seed Proanthocyanidins & Colon
Dietary CLA & Apoptosis (Rats)
HRT & Colorectal Adenoma Recurrence in Women
Mechanisms/Anticarcinogenic Effects of Diet-Related Cell Death
Daily Multivitamin With FOLATE
Vitamin D Fights Colon Cancer
Vitamin E succinate-colon ca cells
Flavinoids & Colon CA Cells
Tongue Diagnosis for Colon Cancer?
Deguelin Inhibits Growth of Cells
Preventive Effect of Fermented Brown Rice/Rice Bran
Dietary Capsaicin & Rotenone for Chemoprevention
Diarrhea & Colon Cancer
Green/White Tea = NSAIDS & Colon Tumors
Effects of Natural Chemoprevention in Human Colon Ca Cells
Pharmacodynamic Action & Colonic Levels Curcumin
Social Networks & Long-term Colorectal Survivors (Women)
Colon Cancer Abstracts
Assoc of Ampullary & Colorectal Malignancies
RTx-Induced Apoptosis & Rectal Ca
Night-Shift=Melatonin Deficiency=Colorectal Ca Risks
Genetic Signature May Predict Recurrence: Colon Ca
African-Americans More Likely to Die of Colon Ca
Nutritional Intervention RTx & Pelvic Malignancy-NEEDS STUDY
Siblings Needed For Colon Cancer Study
RCT Adjvt TX Colon Ca: 10 Yr Results Surg=Chemo=Immuno
Terminalia catappa (Herb) is Chemopreventive (Rats) Colon
Morning Colonoscopies BETTER
Sexual Dysfunction AFTER Rectal Ca Surgery
Effects of Ascorbic Acid on Rectal Polyps:Familial Polyposis
Chinese Medical Herbs for Chemo ‘Side’ Effects:Colorectal
Protocol: Talk to Your Doctor: Colon Cancer
Immune Supression & Colorectal Cancer
Oral Glutamine Effective Prevents Oxaliplatin-Induced Neuropathy Colorectal Ca Pts
Patient perspective on Ileostomy

Published in Cancer Detection and Prevention 2000; 24(3):295-303.

Nutrients & Risk of Subtypes of Esoph/Gastric Ca
Dietary Protective & Risk Factors (China)
Red Meat Linked to Stomach & Esoph Ca
Bacteriostatic effect of dill, fennel, caraway & cinnamon extracts against Helicobacter pylori
Dietary Patterns & Adenocarcinoma Esophagus/Distal Stomach
Bacteria and Stomach Cancer: Study
Various Vitamins and Stomach Cancer Mortality (US)
Acupuncture Relieves Xerostomia
Immunonutrition Improves Gastric Ca Surgery
Peppermint Oil Inhibits GI Spasms
Patient Experiences/Expectations After Esophageal Surgery
Green Tea:Prevent Oral Ca in Smokers
Nutritional Intervention BENEFICIAL With Radiotherapy
Gastric/Aerodigestive Ca Abstracts
Gastric Surgery Associated with Risk of Laryngeal Cancer
Ginkgo biloba Inhibits Gastric Ca Cell Growth
Marrow Cells Spawn Stomach Cancers
After Surgery Feeding w/Omega-3 Esophageal Cancer
Bone disorder and vitamin D after gastric cancer surgery
Chinese Herbs of Shenghe Powder Reverse Multidrug Resistance of Gastric Carcinoma
GIST specific
Osteopathic support for a survivor of gastric cancer
Radiofrequency Ablation (RFA): Barrett’s esophagus
Her2 testing in gastric cancer
Frank C. Garland: Esophageal Cancer 2010

Various studies, Links

Established 8/06

Chemoradiotherapy in gallbladder cancer
Review of gemcitabine in biliary tract carcinoma
Gallstones & risk of biliary tract cancer: China

Eur J Clin Nutr, 11/02

Less Local Wound Complications

Health Behaviors Linked to Survival in Head/Neck Ca
Lycopene Stops Prlfrtn of Human Oral Ca Cells
Pretreatment Swallowing Exercises – Improve Head/Neck CA Pts
High Intake of Vegetables/Fruit Protective For Oral Ca
Honey Reduces Mouth Sores from RTx
Long-term NSAID Use Reduces Risk:Oral Ca
Saliva & Pathogenesis of Oropharyngeal Ca
Speech Possible AFTER Tongue/Voice Box Removal
Curcumin Inhibits Growth Head/Neck Squamous Cell Ca
RTC Arginine-enhanced Formula & Early Postsurgical Head/Neck
Head & Neck Cancer Abstracts
Head and Neck Organizations
Tumors of Familial Origin: Head & Neck
Epstein Barr Virus & Nasopharyngeal Carcinoma
Pituitary Tumors
Oral Rinse May Detect head/neck squamous cell carcinoma
Phase I-II Study Acupuncture-like Nerve Stim:Head/Neck Ca
Custom-built Bioengineered Jaw
Herpes oncolytic therapy of salivary gland carcinomas
Salivary Proteomics:Oral Squamous Cell Ca Biomarkers
Lymphedema in Head/Neck Cancer Issues
Acupuncture for Xerostomia (Saliva Problem)
Darbepoetin Worsens 5-Year Survival in Head and Neck Cancer
Pemetrexed/Cisplatin Combo NO GOOD

J Cancer Causes & Control, 4/02

Cryotherapy for Kidney Cancer
NCI :Ashkenazi Jews/ Family w/Kidney Ca
CoQ10 Benefits for End-stage Renal Failure
Kidney Ca in Postmeno Women
Kidney Cancer Identified by Urine
Nigella sative (Herb) & Early Carcinogenesis (Rats)
Percutaneous Radio Frequency Ablation
Son Comments on Father’s Use of Galavit
Fish Consumption Reduces Renal Cancer Risk
Milk Thistle Protective: cisplatin-induced renal toxicity
Editorial on Zoledronate & ONJ
Lifetime physical activity and the risk of renal cell cancer
Fibre intake and renal cell carcinoma
Skin toxicity from chemo- and targeted therapy
Sunitinib (Sutent) May be CardioTOXIC for Renal Cancer

Various articles, links, etc.

Bone Mass & Vit D Deficiency
Walking Intervention: Fatigue Experiences of Hospitalized AM L Pts Undergoing Chemo
Clinical trial: vit C against non-Hodgkin lymphoma
White Bld/Neutrophils Rise w/Massage
Nitric Oxide Against Leukemia
Future Cancer Risk for Stem Cell Transplant Patients
Aspirin & Reduced Leukemia Risk
Link Between Maternal Diet and Childhood Leukemia Risk
Body RTx / Hyprthrmia:Dendritic Immnthpy
Leukemia/Lymphoma Abstracts
Lymphoma Issues
Info Natural Therapy Leukemia/Lymphoma
Yeast Infections & Leukemia
Recovery/Long-term Function AFTER Transplant
Be ADVISED: AML Unanswered Questions
Ecstasy & Antidepressants Block Cancer Growth: Leukemia
Leukemia and Lymphoma Groups
Protective effect of hawthorn extract:cyclophosphamide (Mice)
Forskolin Suppressive of Leukemia Progression
Trisenox & Vit A Analog for APL
Combined Chemo Improves CLL Outcomes but Not Survival
imatinib (Gleevec)
Dasatinib Therapy for Leukemia May Lead to Lung Problems
Synergistic Reversal effect quercetin & hyperthermia: doxorubicin
Fatty Acid to Enhance Anticancer Drug Azacytidine
Drug Interactions with Tyrosine Kinase Inhibitors (CML)
Doctor Writes About 2 Weeks in the Transplant Unit

Selective Internal Radiation


TACE Shrinks Tumors
Liver Cancer and Radiofrequency Ablation
Prognosis of Pts w/ Metastatic Hepatocellular Ca
Role of Vitamin K2: Prevent Hepatocellular Ca
Link Between Chronic Hep B & Liver Cancer Sought
Liver Protection w/Amoora rohituka
Tocotrienol-rich Fraction from Rice Bran Oil & Hepatocarc (rats)
Ginseng and Quality of Life
Assessing the effects of cannabinoids w/ a less jaundiced eye
Analysis Validates Reduced Risk of Liver Ca by Coffee Drinking
Silibinin reduces the growth of Liver Cancer (cell culture)
Photodynamic Therapy & Stents for Liver Cancer

Studies in Nutrition

and Lung Cancer

NO Benefit for Adjuvant Chemo in NSCLC BUT…
Isotretinoin (retinoid, Vit A deriv) Not Helpful w/smokers
Lung Cancer: Studies and Issues
Fruit/Veg & Lung Cancer Risks
Lung Cancer Abstracts
Smoking Issues
Lung Cancer & Early Detection
Lung Ca Risk w/ Breast Ca Smokers
Carrots/Tomatoes For Prevention
Dietary Supplements in Lung Cancer
Retinoids & Lung Ca-Right Population Needed
Breath Test & Post-Operative Health
Concentrated Carcinogens in Lung
Antioxidants:Vit C/E & Female Smokers
Mesothelioma Issues
Chlamydia pneumoniae & Lung Cancer: Epidemi Evidence
Lung Cancer Abstracts
Aspirin Cuts:Bowel, Lung, Mouth,Throat, Esophagus Risk
Lung Cancer Advocacy/Support Groups
High Levels of Vitamin D Better Lung Ca Survival
Nutritional status affects long term survival after lobectomy for lung ca

Tim Bolen reports

on NEJM article,


Living Proof-book on CAM & Multiple Myeloma
RTC Home-based Exercise: Pts Treated for Multiple Myeloma
Turmeric & Blood Cancer
Trisenox w Vit C & Low Dose Melphalan
Lower Dose of Thalidomide As Effective: Multiple Myeloma
New Recs for Bisphosphonates: Multiple Myeloma
Oridonin Inhibits Lymphoid Ca Cells(Rabdosia rubescens)

New England J of Medicine, 12/01

Articles, links, issues

Lacrimal Duct & Ocular Toxicity from CMF
Treatment with High-dose IV Methotrexate Extends Survival
Test for Metastatic Potential of Ocular Melanomas

Gut, 2002

Serum Cadmium Levels in Pts w/Pancreatic Ca: Egypt
Nutri Links to Plausible Mechanisms Underlying Panc Can
Physical Activity Decreases Risk:Pancreatic Ca
Nutrition & Pancreatic Ca
Aspirin May Increase Risk of Pancreatic Ca in Women
Pancreatic Abstracts
Fish Oil and Wasting (Cachexia)
NCPB Improves Pain Relief BUT Not QoL/Survival
Chemotherapy Better than Radiation: Pancreatic Ca
Stimulation of NK cells, Pancreatic Ca w/Virulizin
Pancreatic Cancer Groups
Pt w/Pancreatic Ca and Alternative Treatments
Vitamin D Reduces Pancreatic Cancer Risk
Complementary Approach to Pancreatic Cancer
Small, asymptomatic neuroendocrine pancreatic tumours
Press Release: Rash in Cancer Pts treated w/erlotinib (Tarceva)
Triptolide Induces Pancreatic Cancer Cell Death
Phase II Trial Curcumin – Patients w/Advanced Pancreatic Ca
ALA/N (alpha-lipoic acid/low-dose naltrexone) for PanCan
Jefferson Thomas, Pancreatic Cancer

Studies, article, links and

patient perspectives

PROSTATE Cancer Groups Links
Nutrition, Prostate Cancer & Cancer Risk
Excercise, Cryoablation, and More: Prostate
Herbs and Supplements for Prostate Cancer
Intn’l Conf on Prostate Cancer, 2006
Prostate Cancer – RACE
Earl Woods, 74, Father of Tiger Woods – Prostate Cancer
Summary Reports Prostate Cancer conferences

Cancer, 10/03

Long-term Complications:Ewing Sarcoma Treatment
Natural substances for Sarcoma
Synovial Sarcoma: National Cancer Institute Info
Angiosarcoma of the Breast
Story of Brett, Age 13 and Ukrain
Soft Tissue Sarcomas Much Better Outcomes at High-Volume Centers
Sarcoma Organizations
Morphine treatment accelerates sarcoma-induced bone pain (MICE)
Antitumor Effect of Stilbenoids from Vateria indica
effectiveness of chemotherapy accurately determined in sarcoma patients
Transcervical Biopsy – Uterine Sarcoma/Benign Leiomyoma

Series of studies,

varous journals

assembled by Medscape

Green Tea & Skin Protection
Melanoma Issues
Topical EPA Protective of UVB (Mice)
Vitamin E Protective
Antioxidant Effects of Extract from Leaves
Oxidative Targets in the Stratum Corneum
Topical/Oral Reduces Papillomas in Mice
Topical L-ascorbic Acid
Cream to Prevent Skin Cancer
Second Primary Cancers in Pts w/Squamous Cell Ca SKIN
Skin Cancer Info/Am Acad Of Derm.
DNA Repair Could Reduce Sunburn
Sun Lamps Double Risk of Some Skin Cancer
Using Vitamin A Analogue with Interferon/chemo
Lutein for Skin (Spinach & Leafy Green Vegs)
Caffeine Protection from Ultraviolet RTx (mice)
Photonics & Early Skin Ca Detection
Homeopathy for Dermatologists
Various Fruits Are Protective for Skin Cancer
Skin Cancer Abstracts
Free-Tissue Transfer : Skin Cancer
Skin Cancer in Skin of Color
Skin Cancer & Melanoma Organizations

Nutrition and Cancer, 1999


Testicular & Dietary Issues-Full Text
Testicular Exam/Self Exam
Cardio Disease:Complication of Testic Ca Treatment
Distress, QoL: Testicular Ca & Chemo
Mortality After Cure of Testicular Seminoma
Family Risk in Testicular Ca
Fertility, Gonadal & Sexual Function: AFTER Testicular Ca
Testicular Cancer Links
Testicular cancer (TC) and Late Effects

Cancer Causes and Control, 12/01

Tell Your Cancer Story to Natl Acad of Sciences
Foods, Occupations & Family History Factors in Thyroid Ca
Recurring Health Problems After Thyroid Ca
Fine-needle Aspiration & Correlation w/Histopathology:Thyroid
Interpreting I31I Scans: False Positives
Unwanted Effects (Bone): Long-term Levothyroxine
Thyroid Cancer
Thyroid Issues in Persons Exposed to Iodine 131
LINKS to Thyroid Groups/Info
Anaplastic thyroid cancer & primary thyroid lymphoma
Favorable outcomes with/wo treatment for papillary thyroid ca

Articles, links, etc.

Survival teenagers & young adults in England, 1979–2003
Young Adult Patient/Survivor Groups
Most Common Cancers in Ages 15-29
Young Adult Patient/Survivor Groups

J Am Diet Assoc, 3/03

LINK to website w/lots of


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