Yondelis™ (ET-743) Phase II Johnson & Johnson, Pharmaceutical Research & Development Raritan, NJ and PharmaMar USA, Cambridge, MA (800) 817-5286 Yondelis is a new anti-tumour drug derived from the marine organism, Ecteinascidia turbinata, a 'sea squirt', or tunicate, found in the Caribbean and Mediterranean seas. It is a naturally occurring compound in that it is produced by a living marine organism. Yondelis (ET-743) has been extracted from naturally growing and farmed Ecteinascidia turbinata, and a hemisynthetic process has been developed so that the drug may be manufactured chemically. It is commonly agreed that ET-743 binds to the minor groove of the DNA and inhibits cell proliferation, leading to p53-independent apoptosis of cancer cells. It was developed by a Spanish company called PharmaMar that specializes in anti-tumor drugs from marine sources. More at http://www.pharmamar.es Ann's NOTE: This information came to us as a result of a woman on the trial who posted to the BC METS list. She was telling the others that she has had good results with this product. LINK to maker of this substance/product Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.