Vitamin E Suppresses Androgen Receptor, PSA Expression in Prostate Cancer NEW YORK May 28, 2002 (Reuters Health) Results of experiments in prostate cancer cells indicate that alpha-tocopheryl succinate (VES) suppresses the expression of prostate-specific antigen (PSA) and androgen receptors (AR), researchers report in the May 28th issue of the Proceedings of the National Academy of Sciences. Dr. Shuyuan Yeh and colleagues, from the University of Rochester, New York, also found that the inhibition of androgen receptors by VES is selective, since there is no repression of other nuclear receptors. In studies with LNCaP prostate cancer cells, VES inhibited the growth of these cells. Compared with hydroxyflutamide, which only slightly inhibits LNCaP cell growth, the combination of hydroxyflutamide and VES significantly reduced cell growth, Dr. Yeh's team found. They also report that although selenomethionine did inhibit LNCaP cell growth, it did not affect the AR/PSA pathway. Dr. Yeh and colleagues conclude that "together, our data indicate that VES may suppress androgen/AR-mediated cell growth and PSA expression by inhibiting AR expression at both the transcription and translation levels." They add that "our results may contribute new knowledge to understand the vitamin E-mediated suppression of prostate tumor growth, which may help to design a better therapeutic treatment for prostate cancer patients." SOURCE: Proceedings of the National Academy of Sciences 2002;99:7408-7413. Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.