Vitamin D and Breast/Ovarian Cancer

Vitamin D and breast cancer.

Christakos S Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.

1. 1,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in addition to regulating calcium homeostasis, also has antiproliferative and prodifferentiating effects. 2. Most studies concerning the therapeutic potential of analogs of 1,25(OH)2D3, which are antiproliferative and prodifferentiating but do not cause hypercalcemia, have been done using leukemic cells. 3. Recent evidence from both in vivo and in vitro studies has indicated that 1,25(OH)2D3 or analogs of 1,25(OH)2D3 can inhibit the growth of breast cancer cells, thus suggesting the therapeutic potential of analogs of 1,25(OH)2D3 in the treatment of breast cancer.


Vitamin D Gene Variant Linked to Breast Ca

Reuters Health 10/05/01 British J of Cancer

Dairy/Calcium/Vitamin D-Risk of Bca

JNCI, 9/02

Diet, Supplemental Use/BCA:Vitamin D Role

Abstract #C141 Frontiers in Cancer Prevention Res, 2003

Vitamin D (Sunlight ) Better Prognosis: Prostate, Breast, Colon

Cancer Causes & Control, 3/04

Vit D, Calcium & Mammographic Breast Density

Cancer Epid, Biomarkers & Prevention, 9/04

Vit D Impact on Breast & Ovarian Cancers

AACR, 2006

Vit D for Fatigue/Muscle Pain in Women W/Early-Stage Brst Ca

Abstract 6075 San Antonio Breast Cancer Symposium


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