High-Fat Corn Oil Diet Promotes the Development of High Histologic Grade Rat DMBA-Induced Mammary Adenocarcinomas, While High Olive Oil Diet Does Not Irmgard Costa Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medical School, Universitat Aut¨°noma de Barcelona, Spain; Department of Pathology, Hospital General de Granollers, Barcelona, Spain Raquel Moral Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medical School, Universitat Aut¨°noma de Barcelona, Spain Montserrat Solanas Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medical School, Universitat Aut¨°noma de Barcelona, Spain and Eduard Escrich Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medical School, Universitat Aut¨°noma de Barcelona, Spain Abstract Effects of a high corn oil and a high olive oil diet on the histopathologic characteristics of rat dimethylbenz(¦Á)anthracene-induced mammary adenocarcinomas were investigated in comparison with those of a control low-fat diet. Two experimental series (A and B) studied the influence of a high corn oil diet on the initiation and the promotion of mammary carcinogenesis, while another one (C) assessed the effects of the two dietary lipids on the promotion. Nine parameters have been analyzed and a new histologic grading method, adapted to rat tumors, has been applied in each carcinoma. High corn oil diets, particularly when acting as promoters, associated with higher-grade carcinomas than control (p < 0.05) and high olive oil groups. Stromal invasion and tumoral necrosis were more prominent and a prevailing cribriform pattern was observed (p < 0.05). High olive oil diet adenocarcinomas exhibited a predominantly low histologic grade and few necrotic and invasive areas, similar to the control, and they presented the highest percentage of papillary areas. Lymphoplasmacytic and mast cell infiltration were also influenced by the dietary lipids. Thus, high corn oil diet adenocarcinomas presented a higher degree of morphological malignancy than control and high olive oil tumors, which is in line with the greater clinical malignancy described in rats from the former group and the non-promoting effect of the high olive oil diet. As far as we are concerned, a similar histopathologic approach of the effects of the dietary lipids on experimental breast cancer has not been carried out up to now. Export Citation: Text RIS doi:10.1023/B:BREA.0000036896.75548.0c Breast Cancer Research and Treatment 86 (3): 225-235, August 2004 Article ID: 5271305 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.