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Tamoxifen (and SERMS)

Articles on Tamoxifen and Raloxifene can be found here. Ann Fonfa testified at the 9/2/98 FDA Oncological Advisory committee when approval was granted for Tamoxifen use by healthy women.

Along with other activists who spoke passionately about their fears, confusion and general disillusionment with the drug, Ann remains very unhappy about the way the results of this study were reported on and promoted.

Please look at these articles, each of which stands alone as written at various times.


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padRandom Thoughts on the PREVENTION trials
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Tamoxifen and Raloxifene 8/99
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Canadian Analysis Finds No Improved Survival
Raloxifene:Benefits versus Risks
Benefit Greatest to Prevent Hormone-Dependent Bca
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padSPORE Study: New Guidelines for Tamoxifen Use
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NCI Bulletin, 12/06
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padLow Dose Tamoxifen Effective: 1/20th?
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Am Assoc for Cancer Research, 4/03
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Press Release: Tam Effective at Lower Doses
2 Years Vs. 5 Years for Early Bca Age 50+
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padExcerpts:7th Intl Conf Adj Therapy
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February 2001, Switzerland Includes basic info on the BCPT1
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padDrug Costs
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A Comparison of Prices with some LINKS to Canadian pharmacies
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padBCPT1:Tamoxifen hearings 1998
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Perspective and summary from Sharon Batt, a Canadian activist
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Ann Fonfa's Testimony to the FDA 9/2/98
Washington Post Coverage, 9/98
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padGail Model May Fail Women Under 40.
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Journal, The Breast February 2001
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Canada: Net Health Impact of Tamoxifen
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padSafe for Fewer Healthy Women
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November 3, 1999 JNCI article
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Study: Tamoxifen & Uterine Tumors
Tamoxifen Eligibility:PREVENTION in White Women
Tamoxifen Useful for Women 40-50 with 3.4% Five-Year Risk
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padEurope: Benefits/Risk of Tamoxifen-Healthy Women
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Federation of European Cancer Societies 3/02
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padTamoxifen and ER- Tumors
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Another study demonstrates NOT helpful in Stage 1 ER-.
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padEra Of Hope Speech
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Helen Schiff's passionate presentation on Tamoxifen for healthy women, 6/00
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Questions and Answers on Tamoxifen
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padPress Release: Cancer Prevention Coalition
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Barbara Seaman and Ann Fonfa also sign on to release
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padLetter: Wall Street Journal 1998
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Written by Carol Hochberg and Ann Fonfa
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padIUD May Protect Tam Users
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Study, The Lancet 11/00
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padSTAR Trial
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An article by Andrea Martin, Exec. Dir. The Breast Cancer Fund
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Effect of Raloxifene on Bca Cell Ki67 and Apoptosis
Tam, Raloxifene Show Preclinical Cross-resistance
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padTamoxifen & Beneficial Interactions
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Cancer Letter 2000. early study results
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Tamoxifen for Five Years
GLA and Tamoxifen May Down-Regulate ER Pathway
Black Cohosh & No Proliferation of Bca Cells
Tamoxifen Plus Soy Prevents Bca in Rats
Melatonin & Tamoxifen Good Combo
IP6 Enhances Adriamycin & Tamoxifen (Bca)
EPA Restores Tamoxifen Sensitivity (Akt activity)
Flaxseed Enhances Inhibitory Effect of Tamoxifen: ER+ Bca
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padSymptoms & Adverse Effects: Reporting
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Journal-The Breast, April 2001
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Adverse Effects Not Properly Recorded
Tamoxifen & Depression
Toxicity of Antiestrogens
Tamoxifen Controversy-Negative Effects
Verbal Memory Impaired with Hormonal Therapy
Changes in Serum Triglycerides w/Tam
Gallstones Linked to Tamoxifen Use: Postmenopausal
Coagulation Behavior With Adj Post-op Tamoxifen
C-erb B2 Decreases Benefit of Adj Tam
Venous Thrombosis BCa Tamox/Chemo: Review
Tamoxifen w/Radiotherapy: CAUTION for Radiosensitive Pts
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padTamoxifen for High Risk and BRCA1/2
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Lancet, December 2000
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Most Women with Family Hist DO NOT Get Bca
Tamoxifen and BRCA Mutations
Estimates of Prophylactic Effects of Tamoxifen *BRCA1&2)
Breast Cancer Prevention-UK Study
Breast Gel Version of Tamoxifen
Tamoxifen/Chemoprevent/BRCA1/2:Docs Recommendations
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padChemoprevention Guidelines From Canada
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Canadian Medical Association Journal, June 2001
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Britain's Dept of Health Says No to Tamoxifen in Healthy Women
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padTamoxifen and Risk of Contralateral Bca
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JNCI,7/01
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Author Musa Mayer Remarks on this Study
AP's Take:ER negative tumors develop After Tam Use
DNA Methylation Prfle Predicts Recurrence Risk:Tam/BCa
Benefits/Risk Tamoxifen Similar White & Black Women
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padTamoxifen and Breast Tumor Vascularity
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Breast Cancer Res Treat, 2001
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padTam & Serum Leptin in Bca Pts
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Jpn J of Clinical Oncology, 12/01
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Tamoxifen's Effectiveness & Slow version of a Gene
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padFDA Warns AstraZeneca Over Ads
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1/16/02 Reuters and FDA Website
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padEstrogen Level = Effect of Raloxifene
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JAMA, 1/02
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Cross-Resistance Tam Vs. Ralox
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padUK: Healthy Women,No Clear Benefit
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The Oncologist, 2/02
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Risk/Benefit in Int'l Intervention Study
Update on Royal Marsden Tamoxifen Prevention Trial
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padAromatase Inhibitors/Estrogen Dominance
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Peter D'Adamo, ND perspective, 2001
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Use of Adjv Chemo in ATAC Trial-Nationality Correlates
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padComparison of SERMS & Tamoxifen (MICE)
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Intl J Cancer, 4/02
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Age/Body Mass Affects Dose
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padFDA Presents: Tamoxifen & Uterine Sarcoma
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Cancer Information Service Reports on ASCO 2002 presentation
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Uterine Sarcoma Risk
Advocate Letter to FDA on Warning Labels, 2002
Risk Maliganant Mixed Mullerian Tumors *(Uterine)
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padHEALTHY PREVENTION
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Some advice, information, and tips But mostly you must make your own informed decision
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padRecommendations: US Prev Svcs Task Force
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Annals of Internal Medicine, 7/02 VERY IMPORTANT INFORMATION
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padTest  Developed: Who Needs Tamoxifen
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Oncogene, 7/02
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padAge/Body Mass Index Affect Tam Metabolism
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Presented at Dept of Defense Breast Cancer Res Conference, 9/02
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padTamoxifen &  Benign Breast Disease
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JNCI, 2/03
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padAIB1, Tam, Survival Issues
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Press Release, JNCI 3/03
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padAcupuncture for Meno-symptoms w/Tamoxifen Use
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Tumori, 3-4/02
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padTamoxifen for Women with Breast Ca:Basics
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Univ of Maryland, 5/03
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padAntidepressants supress Tamoxifen's Value
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JNCI, 12/03
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padRaloxifene & Pre-menopausal Women
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#A193 Frontiers in Cancer Prevention Res, 2003
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padEndocrine Therapy Better Than Chemo? ER+
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SABCS, 12/03
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Tamoxifen has Little Impact on Mortality
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