Studies on Resveratrol

Fed Am Soc for Exp Bio, 5/04

Anticancer Research, 2004

Cancer Letters, 5/07

The following list of studies was recently sent to us. Many are shown on our site:

1. Schneider Y, Vincent F, Duranton B, Badolo L, Gosse F, Bergmann C, Seiler N, Raul F. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 2000 Sep 29;158(1):85-91.

2.Szende B, Tyihak E, Kiraly-Veghely Z . Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Exp Mol Med 2000 Jun 30;32(2):88-92.

3. Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin PM, Castanas E. Potent inhibitory action of red wine polyphenols on humanbreast cancer cells. Cell Biochem 2000 Jun 6;78(3):429-41.

4. Tsan MF, White JE, Maheshwari JG, Bremner TA, Sacco J . Resveratrol induces Fas signalling-independent apoptosis inTHP-1 human monocytic leukaemia cells. Br J Haematol 2000 May;109(2):405-12.

5. Hsieh TC, Wu JM. Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism. Anticancer Res 2000 Jan-Feb;20(1A):225-8.

6.Gautam SC, Xu YX, Dumaguin M, Janakiraman N, Chapman RA. Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant 2000 Mar;25(6):639-45

7. De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. .Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica 2000 Jun;30(6):609-17

8. Delmas D, Jannin B, Malki MC, Latruffe N. Inhibitory effect of resveratrol on the proliferation of humanand rat hepatic derived cell lines. Oncol Rep 2000 Jul-Aug;7(4):847-52.

9. Mitchell SH, Zhu W, Young CY. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Cancer Res 1999 Dec 1;59(23):5892-5.

10. Elattar TM, Virji AS. The effect of red wine and its components on growth and proliferation of human oral squamous carcinoma cells. Anticancer Res 1999 Nov-Dec;19(6B):5407-14.

11. Surh YJ, Hurh YJ, Kang JY, Lee E, Kong G, Lee SJ. Resveratrol, an antioxidant present in red wine, inducesapoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 1999 Jun 1;140(1-2):1-10.

12. Jang M, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Drugs Exp Clin Res 1999;25(2-3):65-77.

13. Pancreas 2002 Nov;25(4):e71-6. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Ding XZ, Adrian TE.

14. Blood 2003 Apr 10; [epub ahead of print]Resveratrol blocks interleukin-1{beta}-induced activation of the nuclear transcription factor NF-{kappa}B, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB.

15. Carcinogenesis 2002 Aug;23(8):1327-33. Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Ferry-Dumazet H, Garnier O, Mamani-Matsuda M, Vercauteren J, Belloc F, Billiard C, Dupouy M, Thiolat D, Kolb JP, Marit G, Reiffers J, Mossalayi MD.

16. Leuk Lymphoma 2002 May;43(5):983-7 Anti-leukemia effect of resveratrol. Tsan MF, White JE, Maheshwari JG, Chikkappa G.

17. World J Gastroenterol 2003 Mar;9(3):408-11. Resveratrol induces apoptosis in human esophageal carcinoma cells. Zhou HB, Yan Y, Sun YN, Zhu JR.

18. Cancer Lett 2003 Feb 20;190(2):157-63. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Niles RM, McFarland M, Weimer MB, Redkar A, Fu YM, Meadows GG.

19. Urol Oncol 2002 Nov-Dec;7(6):223-7. Resveratrol-A prostate cancer chemopreventive agent?. Ratan HL, Steward WP, Gescher AJ, Mellon JK.

20. J Urol 2002 Aug;168(2):748-55. Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. Lin HY, Shih A, Davis FB, Tang HY, Martino LJ, Bennett JA, Davis PJ.

21. Curr Med Chem Anti-Canc Agents 2003 Mar;3(2):77-93 Resveratrol and cancer: chemoprevention, apoptosis, and chemo-immunosensitizing activities. Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y, Bonavida B.

22. Int J Cancer 2002 Apr 10;98(5):761-9 Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ.

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