Smoking, drinking, & hair-dye use and the risk of adult leukemia in Shanghai Olufemi J. Adegoke, Martha Linet, Xiao Ou Shu, Maureen Sanderson, Fan Jin, Cheryl L. Addy, Wei Zheng. Dept. of Surgery, School of Medicine, Meharry Medical College, Nashville, TN; Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD; Department of Medicine and Vanderbilt-Ingram Cancer Center, Nashville, TN; University of Texas School of Public Health at Brownsville, Brownsville, TX; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; Department of Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, SC. The association of smoking, drinking, and hair-dye use with the risk of leukemias and the subtypes was evaluated in 486 leukemia subjects and 502 randomly selected age- and sex- frequency-matched controls in a population-based case-control study conducted among adult residents of Shanghai during 1987 to 1989. Structured-interview information was obtained in-person from 255 cases (52%) and from a surrogate for cases that were either deceased (N=194) or too ill to be interviewed (N=37). Odds ratios (ORs) were adjusted for age, sex, and income group. The results for smoking and drinking were inconsistent and showed no significant association with the risk of leukemia, however, an increased risk for CLL among ex-smokers (OR=3.6, 95% CI=1.1-11.5) compared to never smokers and a reduced risk for all leukemias in the ever drink subjects compared to the never drink subjects (OR=0.9, 95% CI=0.6-1.3) were observed. No significant dose-response relationship was identified for either smoking or drinking with the risk of leukemia. Ever use of hair-dye increased the risk for all leukemias (OR=2.4, 95% CI=1.1-5.2) and for CML (OR=4.6, 95% CI=1.7-12.7) significantly among males. Similarly, a borderline statistically significant increased risk for CML was observed for ever use of hair-dye among all participants (OR=2.0, 95% CI=1.0-4.3). We conclude that smoking increases the risk for CLL though we noted this increase among ex-smokers only. Our results further suggest that the use of hair-dye may increase the risk for leukemias, especially CML and this was more demonstrable in males. AACR Abstract Number: 1563, 2003 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.