Skin Tumors Inhibited by Cannabinoid Receptors

Therapeutics

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors

Casanova, M.L. et al.

Cannabinoids have previously been shown to inhibit the growth of gliomas, so Casanova et al. investigated whether they could have a similar effect on non-melanoma skin cancer — one of the most common tumour types.

The cannabinoid receptors CB1 and CB2 are expressed in the skin, and their activation by a CB1/CB2 agonist results in apoptosis of tumorigenic skin cells, and growth inhibition and impaired angiogenesis of malignant tumours in nude mice.

Nature Reviews Cancer, 2/03 of J. Clin. Invest. 111, 43–50 (2003)

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