Research Communication Selenium-Enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice Cindy D. Davis1, Huawei Zeng and John W. Finley U. S. Department of Agriculture, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034 1To whom correspondence should be addressed. E-mail: cdavis@gfhnrc.ars.usda.gov Multiple intestinal neoplasia (Min) mice are a good model for the investigation of the effects of dietary alterations in a genetic model for intestinal cancer. Previous studies have shown that selenium-enriched broccoli is protective against chemically induced colon cancer susceptibility. This study investigated whether selenium-enriched broccoli would be protective against intestinal cancer susceptibility in Min mice. Five-week-old heterozygotic male Min mice were fed an AIN-93-based diet containing either low-selenium broccoli or an equivalent amount of high-selenium broccoli for 10 wk. Mice fed the selenium-enriched broccoli had fewer (P < 0.02) small intestinal (46.4 ± 3.7 vs. 65.6 ± 6.1) and large intestinal (0.43 ± 0.17 vs. 1.93 ± 0.27) tumors than those fed an equivalent amount of unenriched broccoli. Min mice fed the selenium-enriched broccoli had small but significant (P < 0.0001) increases in plasma and liver selenium concentrations and red blood cell glutathione peroxidase activity. These results extend previous observations that selenium-enriched broccoli is protective against chemically induced mammary and colon cancer in rats. © 2002 The American Society for Nutritional Sciences J. Nutr. 132:307-309, 2002 Food Additives & Contaminants, 2/05 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.