ABSTRACT: Role of a 10-Gy boost in the conservation treatment of early breast cancer: results of a randomized clinical trial in Lyon, France Purpose: To define the role of a 10-Gy boost to the primary tumor in the conservative treatment of early infiltrating breast carcinoma treated by limited surgery and radiotherapy. Results: First results, with a median follow up time was 3.3 years as of September 94 were published in JCO 1997. At 5 years, the Kaplan Meier estimate of local relapse rate was 3.6% in the boost group and 4.5% in the no boost group (p = 0.044). After adjustment for the main prognostic variables such as presence of an extensive in situ composant in the periphery of the tumor, maximal diameter of the tumor, degree of histologic differentiation, age at the inclusion, no free margins, the relative risk was still significantly lower for the boost group. In September 2000, Bartelink publish the first results of the EORTC boost trial with comparable results, demonstrating that a boost significantly improves local control. Currently, we are updating our results in terms of local relapse rate, disease free survival, metastasis free survival, and overall survival. The occurrence of local relapse was recorded, to day in 768 patients at 10 years: 26 in the boost group suffered a local relapse compared with 36 in the control group. However only 4 patients dead of cancer in the control group versus 10 in the boost group. Conclusion: Results of the whole group will be updated at the time of the meeting. 11/29/2001; International Journal of Radiation Oncology, Biology, Physics Cancer online, 2/03 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.