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ABSTRACT: Risk of Subsequent Cancer Following Breast Cancer in
Men
The etiology of breast cancer in men is not well understood. We
assessed the risk of subsequent cancers among all 1788 men diagnosed
with a first primary breast cancer from 1973 through 1996 who
were registered with the Surveillance, Epidemiology, and End
Results (SEER) Program.
Although the overall subsequent cancer
risk in men was not increased (standardized incidence ratio [SIR]
= 0.99, 95% confidence interval [CI] = 0.86 to 1.1), the risk
of contralateral second breast cancer was strongly elevated (12
cases; SIR = 30, 95% CI = 15 to 52).
The risk was higher for
men diagnosed with their first breast cancer before age 50 years
than for older men. There were no major differences in the risk
of contralateral breast cancer associated with different treatments
received for the first breast cancer.
The relative risk of second
breast cancer was substantially higher among men than among women
with breast cancer, but the absolute excess risk was lower. We
conclude that men diagnosed with breast cancer are at high risk
of contralateral breast cancer.
[09/04/2002; Journal of the National Cancer Institute]
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