Original Article Reoperations after prophylactic mastectomy with or without implant reconstruction Sara M. Zion, M.D. 1, Jeffrey M. Slezak, M.S. 2, Thomas A. Sellers, Ph.D. 2, John E. Woods, M.D. 3, Phillip G. Arnold, M.D. 3, Paul M. Petty, M.D. 3, John H. Donohue, M.D. 3, Marlene H. Frost, Ph.D. 4, Daniel J. Schaid, Ph.D. 2, Lynn C. Hartmann, M.D. 4 * 1New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 2Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 3Department of Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 4Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota email: Lynn C. Hartmann (hartmann.lynn@mayo.edu) *Correspondence to Lynn C. Hartmann, Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 Fax: (507) 538-0823 Abstract BACKGROUND The authors characterized the unanticipated reoperations after prophylactic mastectomy, with or without implant reconstruction. METHODS The surgical cohort was comprised of 1417 women with a family history of breast carcinoma. The women received a prophylactic mastectomy with (bilateral, n = 593; contralateral, n = 506) or without reconstruction (n = 318) at the Mayo Clinic (Rochester, MN) between 1960 and 1993. Reoperations and indications for reoperation were compiled from medical records and a patient survey. RESULTS Three hundred eighteen women received a bilateral (n = 39) or contralateral (n = 279) prophylactic mastectomy without reconstruction. With a median follow-up of 15 years, 18 women (6%) required reoperation. Most of these reoperations occurred within the first year after prophylactic mastectomy. Five hundred ninety-three women had reconstruction with implants following bilateral propylactic mastectomy. Approximatelyone-half of the women (52%) required at least 1 unanticipated reoperation during a median follow-up of 14 years. Approximately 39% of all reoperations occurred within 1 year of breast reconstruction and 69% within 5 years. Implant-related issues were the most common cause for reoperation. Some women with breast carcinoma elected to receive contralateral prophylactic mastectomy with therapeutic mastectomy for the affected breast. Five hundred six women received reconstruction with implants. During a median follow-up of 8.8 years, 189 women (37%) required unanticipated reoperation. The most common indication was implant-related issues. The time course of reoperations was similar to that for women in the bilateral group. CONCLUSIONS Surgical reoperations were fairly common among women who received prophylactic mastectomy with implant reconstruction. Most of the reoperations were implant related. Reoperations were fairly uncommon after prophylactic mastectomy without reconstruction. Cancer 2003. Volume 98, Issue 10 , Pages 2152 - 2160 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.