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ABSTRACT: Cancer and pregnancy: recent developments
PURPOSE OF REVIEW: Breast carcinoma, cervical dysplasia and
cervical carcinoma are some of the most common forms of precancerous
and malignant changes seen in pregnancy due to their prevalence in
reproductive age women.
The impact of pregnancy on these diseases
is complex and needs to be carefully considered for appropriate clinical
management.
RECENT FINDINGS: Recent studies indicate a relationship
between hormone levels during pregnancy and subsequent breast
cancer risk. For women who have already been diagnosed with breast
cancer, retrospective studies show no adverse outcomes on maternal
mortality with subsequent pregnancy.
Prospective studies are
needed to further elucidate these relationships. Recent research
evaluating human papilloma virus in pregnant women indicates
a similar prevalence of disease among pregnant and nonpregnant
patients.
Increased rates of human papilloma virus clearance
postpartum may be related to an increased immune response within
the cervix secondary to the trauma of labor.
For women with early
stage cervical cancer desiring to preserve future fertility,
new trends in treatment allow for preservation of reproductive
function. Few recent studies have been conducted regarding the
use of chemotherapy during pregnancy, but one study reports increased
rates of prematurity after the use of chemotherapy.
SUMMARY: Continued research is needed regarding the management of
breast and cervical cancer during pregnancy in order to optimize
treatments and to further our understanding of these disease
processes.
[11/29/2002; Current Opinions in Obstetrics and Gynecology]
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