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#1141
Pregnancy (PG) in the patient with lymphoma does not predict an adverse prognosis
G. Hu, MA Rodriguez, J Romaguera, P McLaughlin, A Younes, J Cox, J Medeiros, B Samuels, F Caanillas, F Hagenmeister
University of Texas, MD Anderson Cancer Ctr, Houston, TX
Radiotherapy (XT) and chemotherapy (CT) for the pregnant woman with lymphoma involve complex decisions. Because of changes in managementof Hodgkin's disease (HD) and lymphoma (NHL), we reviewed ourexperience in treamtent (Tx) of those patients (PT) over the last 40 years.
Method: We reviewed outcomes of 54 women aged 18-38 (1) treated with coexisting pregnancy and HD (28) or NHL (17), or (2) in whom the diagnosis and Tx of HD (11) or NHL (8) was delayed until postpartum (PP).
Features included trimester (TR), stage (ST), therapy choice (TC) and survival.
Results: ST by TR included:
First TR-ST I/II (6), III/IV (1)
Second TR I/II (17), III/IV (4)
Third TR I/II(6), III/IV (1)
PP I/II (15), III/IV (4)
TC included: abortion (AB) and XT-7;AB and CT-2; AB, CT and XT-16; XT-11; XT and CT-7.
No patient received CT while pregnant. Deliveries were: Normal-18 pts, spontaneous AB while or on early delivery post XT-1 each. CR's were First TR-6/7; Second TR-18/21; Third TR 7/7; PP-18/19.
At a median follow-up of 114 mo (range 12-336), 13 have died of disease; median survival was 114 months for PG (range 12-336) and 124 months for PP patient (range 12-324).
Conclusion: PG and HD or NHL, Tx should be individualized; normal deliveries are possible in most, with a good chance of a cure.
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