ABSTRACT: 1,1-Dichloro-2,2-bis-p-chlorophenyl-ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies Background: Environmental exposure to organochlorines has been examined as a potential risk factor for breast cancer. In 1993, five large U.S. studies of women located mainly in the northeastern United States were funded to evaluate the association of levels of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and polychlorinated biphenyls (PCBs) in blood plasma or serum with breast cancer risk. We present a combined analysis of these results to increase precision and to maximize statistical power to detect effect modification by other breast cancer risk factors. Conclusions: Combined evidence does not support an association of breast cancer risk with plasma/serum concentrations of PCBs or DDE. Exposure to these compounds, as measured in adult women, is unlikely to explain the high rates of breast cancer experienced in the northeastern United States. [05/15/2001; Journal of the National Cancer Institute] Cancer Causes and Control, 6/01 Breast Cancer Res & Treatment 12/01 Am J Epidemiology, 3/02 Serum Organchlorine Residue:Bca Am J Epidemiology, 4/02 Env Exposure to PCB's & Breast Ca:Review of Current Evidence 10/02 In SF Bay area, 1 in 7 rates of Bca SF Women Have 3-10X MORE Pollutants DDT & Metabolites in Breast Milk:Saudi Arabia Organic Dairy/Meat Improves Quality of Mothers’ Breast Milk Breast Cancer Res Treat, 3/02 J Clin Epid, 2000 Clinical Cancer Res, 10/03 Proc Nat Acad Sciences, 4/04 www.silentspringinstitute.org Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.