"My name is Sybil Brabner. I am citing a number of technical articles that helped me make my decision. I am fortunate that I have a good friend who is a biochemist in Cancer Research at a pharmaceutical company. He helped me to understand the science behind this therapy. I am a 37-year-old Breast Cancer patient. My type of cancer usually kills a woman within three years. I was diagnosed in January 1999, Stage IIB, (ER-, PR-, P53+, Her/2-) nuclear grade 3 (Bloom and Richardson). Three out of ten lymph nodes were infected. The cells were very poorly differentiated. After a biopsy (January) and two re-excisions (February and March), I had a mastectomy in April of 1999, followed by four cycles of Adrimycin, Cytoxan, and Taxol at one time three weeks apart (ECOG study). This was followed by six weeks of radiation to the breast area and to the axilla. I had no other symptoms until a metastasis to Lumbar two, which resulted in a fracture by April 1, 2000. In July I was treated for a metastasis to my sacrum and shortly thereafter at the end of August a metastasis to rib two on the left side. It was at this time that they discovered metastasis to liver and lung. On October 3, the liver metastasis measured 6.1cm x 5.9cm. I also had other lesions in my lungs (2cm and larger) and throughout my liver. On September 26, 2000, I started taking 25mg Cytoxan orally (I only weigh 110lbs) combined with 200mg twice a day of Celebrex. On my last scan (November 2, 2000) my liver tumor was 3.4cm x 3.3. Other tumors in my lung and near my spine have disappeared altogether. Bone metastases are stable. I have had no side effects, save for a few hot flushes at night (attributed to tumor breaking up). I am able to eat, exercise, and have not had any immune suppression. I have quality of life, and this is after the doctors said "6 months to a year" to live. The reason this works is it targets the endothelial and stroma cells that make up the blood supply to the tumors. Across humans, these cells are very similar. Conventional chemo targets tumor cells, which we all know adapt and become drug resistant very quickly. Please email me once you’ve reviewed the following and I can explain further if necessary. I want to help as many metastatic patients as I can. I will also send along my radiology reports if you would like. Main article: http://www.jci.org/cgi/content/full/105/8/R15 Other supporting documentation: http://208.243.117.239/prof/me/html/99abstracts/bc/m_460.htm http://www.jci.org/cgi/content/full/105/11/1511 http://www.mmhc.com/hhcc/articles/HHCC0006/kaplanmachlis.html Information on the two drugs I am taking: http://www.rxlist.com/cgi/generic/coxib.htm http://www.bccancer.bc.ca/cdm/monographs/cyclophosphamide.shtml " Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.