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Oral Contraceptives &  Bca/Ovca

Risk of Breast Cancer With Oral Contraceptive Use in Women With a Family History of Breast CancerContext:

Abstract:

Oral contraceptive (OC) use is weakly associated with breast cancer risk in the general population, but the association among women with a familial predisposition to breast cancer is less clear.

Objective: To determine whether the association between OC use and risk of breast cancer is influenced by family history of the disease.

Conclusions: These results suggest that women who have ever used earlier formulations of OCs and who also have a first-degree relative with breast cancer may be at particularly high risk for breast cancer. Further studies of women with a strong family history who have used more recent lower-dosage formulations of OCs are needed to determine how women with a familial predisposition to breast cancer should be advised regarding OC use today.

JAMA. 2000;284:1791-1798


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padOral Contraceptives Do Not Reduce Ovarian Ca Risk
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NE J of Medicine, 2001
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padPill Hormone & Lower Ovarian Risk
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JNCI, 1/02
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padProgesterone and cell death
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In vitro use kills cancer cells
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padOral Contraceptibes Not Linked to Breast Cancer
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Medscape take on NEJM, 2002
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padContraceptive/Repro History & Ova Ca Risk
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Am J Epidemiology, 9/04
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