Nutrient Intake and Risk of Subtypes of Esophageal and Gastric Cancer1 Susan T. Mayne2, Harvey A. Risch, Robert Dubrow, Wong-Ho Chow, Marilie D. Gammon, Thomas L. Vaughan, Diana C. Farrow, Janet B. Schoenberg, Janet L. Stanford, Habibul Ahsan, A. Brian West, Heidi Rotterdam, William J. Blot and Joseph F. Fraumeni, Jr. Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut [S. T. M., H. A. R., R. D.]; National Cancer Institute, NIH, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland [W-H. C., J. F. F.]; University of North Carolina School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina [M. D. G.]; Fred Hutchinson Cancer Research Center, Program in Epidemiology, and University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, Washington [T. L. V., D. C. F., J. L. S.]; New Jersey Department of Health and Senior Services, Cancer Epidemiology Services, Trenton, New Jersey [J. B. S.]; Division of Epidemiology [H. A.] and Department of Pathology [H. R.], Columbia University, New York, New York; New York University Medical Center, Department of Pathology, New York, New York [A. B. W.]; and International Epidemiology Institute, Rockville, Maryland [W. J. B.] Incidence rates for adenocarcinoma of the esophagus and gastric cardia have been rising rapidly. We examined nutrient intake as a risk factor for esophageal and gastric cancers in a population-based case-control study in Connecticut, New Jersey, and western Washington state. Interviews were completed for cases with histologically confirmed esophageal adenocarcinoma (n = 282), adenocarcinoma of the gastric cardia (n = 255), esophageal squamous cell carcinoma (n = 206), and noncardia gastric adenocarcinoma (n = 352), along with population controls (n = 687). Associations between nutrient intake and risk of cancer were estimated by adjusted odds ratios (ORs), comparing the 75th versus the 25th percentile of intake. The following nutrients were significantly inversely associated with risk of all four tumor types: fiber, ß-carotene, folate, and vitamins C and B6. In contrast, dietary cholesterol, animal protein, and vitamin B12 were significantly positively associated with risk of all four tumor types. Dietary fat [OR, 2.18; 95% confidence interval (CI), 1.27–3.76] was significantly associated with risk of esophageal adenocarcinoma only. Dietary nitrite (OR, 1.65; 95% CI, 1.26–2.16) was associated with noncardia gastric cancer only. Vitamin C supplement use was associated with a significantly lower risk for noncardia gastric cancer (OR, 0.60; 95% CI, 0.41–0.88). Higher intake of nutrients found primarily in plant-based foods was associated with a reduced risk of adenocarcinomas of the esophagus and gastric cardia, whereas higher intake of nutrients found primarily in foods of animal origin was associated with an increased risk. Cancer Epidemiology Biomarkers & Prevention Vol. 10, 1055-1062, October 2001 © 2001 American Association for Cancer Research Head Neck, 9/02 J Cancer, 4/03 Nutr & Cancer, 5/03 Gastroenterology, 10/05 Fruit and vegetable intake & esophageal cancer Am J Epidemiol, 2007 Nov Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.