Mining The World's Oceans for Medicinals

Excerpt from American Association for Cancer Researchers "Frontiers in Cancer Prevention Research", October, 2002:

“Mining the World’s Oceans for Medicinals” presented by Chris M. Ireland, University of Utah, Salt Lake City, UT.

“…the oceans represent better than 95% of the biosphere. All but 2 of the 28 principal phyla in the animal kingdom are represented in aquatic environments…”

“…conservative estimates are that there are over 1 million species represented in the world’s oceans.”

Dr. Ireland reported on several substances that his group is looking at including several in Phase I or Phase II, even one in phase III trials.

The names of these may not be spelled totally correctly but:

Cryptophyein – Phase I trial

Ecteinascidin 743 – Phase II

Dolastatin 10 – Phase II

Bryostatin 1 – Phase III

Hemiaserlin – Phase I (not cytotoxic)

Stylissa Massa, Leucetta chagosensis and namidine A. These products come mostly from ocean sponges and may inhibit signaling in the EGFR Pathway, causing cell arrest.


Salinosporamide A-Inhibits Cancer Growth

Scripps Inst of Oceanography, 1/03


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