Metastatic spreading Researchers of the Witten/Herdecke University, Germany, found that the endocannabinoid anandamide has an inhibitory effect on the migration of tumour cells and lymphocytes. The effects on tumour cells were mediated by the CB1 receptor and the effects on CD8(+) T lymphocytes were mediated by CB2 receptors. Thus, cannabinoids that bind to the CB1 receptor would inhibit metastatic spreading. Researchers conclude that "specific inhibition of tumour cell migration via CB(1)-R engagement might be a selective tool to prevent metastasis formation without depreciatory effects on the immune system of cancer patients." (Source: Joseph J, et al. Cancer Immunol Immunother 2004 Mar 18 [Electronic publication ahead of print]) J Molecular Cancer Thera, Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.