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February 6, 2002
Circling the Mammography Wagons
As the debate over the value of mammography intensifies, it is
disappointing that key organizations and individuals in the cancer
establishment have mostly chosen to draw their wagons in a defensive
circle. Now that recent studies have raised serious challenges to the value
of mammograms, other experts need to examine the data with an open mind if
the public is to retain its faith in the recommendations of prestigious
medical organizations.
The prevailing orthodoxy on breast cancer is based on seven major studies
that found mammograms can help save women by detecting tumors early, when
they are most treatable. That conventional wisdom was challenged by two
researchers in Denmark, who concluded that five of the seven studies were
too flawed to warrant much confidence, and that the other two studies taken
in combination showed no evidence that mammography reduced breast cancer
deaths or prolonged women's lives. That conclusion was endorsed by the
editor of The Lancet, a respected British medical journal, and by an expert
group sponsored by the National Cancer Institute whose job is to update the
cancer information supplied to doctors and patients.
This state of affairs can only be described as astonishing. For many years
mammography has been a bedrock of efforts to reduce the toll from breast
cancer, yet now a handful of respected scientists are suggesting that it
may all have been a huge mistake, a misreading of the clinical trials that
were supposed to determine whether mammography helped save lives or did not.
It's not surprising that the cancer establishment, which has devoted so
much effort to persuading women to have mammograms, is unsettled. Its
reaction has been to call on higher authority — itself. In a full-page ad
in The Times last Thursday, 10 health organizations asserted that despite
some flaws in the studies, "the evidence as a whole" solidly supports the
idea that breast cancer mortality rates are reduced by screening
mammography. The statement derived its authority from the prestige of the
signers, which include the American Cancer Society, the American Medical
Association and the American College of Obstetricians and Gynecologists,
among others.
A more technical defense was mounted by scientists at McGill University and
the Weill Cornell Medical College who published a research letter last week
rebutting the critics. But as a defense of mammography, the paper fell far
short of inspiring confidence. The authors relied on a single study that
focused on a narrow range of years after the initial screening. Meanwhile,
a paper published today by scientists at Dartmouth Medical School seemed to
support the mammography critics. It suggests that efforts to assign a cause
of death to any particular cancer are often biased in favor of screening,
as critics of mammography have contended.
At this point, with the debate still unsettled, it seems foolish for women
who have been undergoing regular mammography screenings to abandon their
routines. But a serious and open reassessment of the data is crucial, and
it must be conducted by an organization that can be trusted for its
objectivity. The most credible organization to re-evaluate mammography
might be the National Cancer Institute, which in some past controversies
has shown independence of the cancer organizations, or perhaps the National
Academy of Sciences, which is explicitly designed to perform independent
reviews of controversial issues.
New York Times 2/06/02
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