Presence of Luteinizing Hormone/Human Chorionic Gonadotropin Receptors in Male Breast Tissues Harold E. Carlson, Philip Kane, Z. M. Lei, X. Li and C. V. Rao Departments of Medicine (H.E.C.) and Pathology (P.K.), Stony Brook University, Stony Brook, New York 11794; and Department of Obstetrics, Gynecology and Women’s Health (Z.M.L., X.L., C.V.R.), University of Louisville, Louisville, Kentucky 40292 Address all correspondence and requests for reprints to: Harold E. Carlson, M.D., Endocrinology Division, HSC T15-060, Stony Brook University, Stony Brook, New York 11794-8154. E-mail: hcarlson@notes.cc.sunysb.edu. Receptors for LH/human chorionic gonadotropin (hCG) have been found in a variety of nongonadal tissues including the female breast. Using in situ hybridization and immunohistochemistry, we demonstrated the presence of LH/hCG receptor mRNA and protein in normal male breast tissue obtained at autopsy (n = 4) and archival samples of benign gynecomastia (n = 14) and male breast carcinoma (n = 5). Although the function of these receptors remains to be determined, the findings suggest the possibility that LH and hCG may play a role in the pathogenesis of male breast disorders. The Journal of Clinical Endocrinology & Metabolism Vol. 89, No. 8 4119-4123, 8/04 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.