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DOD-BCR: Lateral lesions associated with better survival rate
in breast cancer
ORLANDO, FL -- September 30, 2002 -- Analysis of data from a Danish
breast cancer registry of 35,319 women indicates that women who
have breast tumors located on the upper lateral quadrant of the
have a 15 to 20 percent better survival rate than women who have
medial or central lesions and the farther the tumor is from the
axilla the worse the prognosis, according to a study presented
Thursday at the Department of Defense Breast Cancer Research
Meeting.
Mads Melbyer, PhD of the department of epidemiology research,
Statens Serum Institute, Copenhagen, Denmark said the survival
difference remained the same regardless of tumor grade or metastatic
state. "We don't really know how to explain this difference.
Except that we can say this: these findings tell us that for
many women we should be able to do better," Dr. Melbye said in
an interview.
Dennis Slamon, MD, PhD chief division of hematology-oncology,
UCLA Medical Center and director of the Revlon/UCLA Women's Cancer
Research Program, said the finding was "surprising, but undeniable.
This is a population study with huge numbers, so this is real."
But he added that the study "needs to be replicated in another
large population study-perhaps another study from one of the
Scandinavian countries-before we can start guessing at the biology
behind it."
Nonetheless, Dr. Slamon suggested that the differences
may be due to "hemodynamic differences in the medial region or
to differences in the tumor biology."
[10/01/2002; Doctor's Guide]
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