Epidemiology Fibre intake and prostate cancer risk Claudio Pelucchi 1 *, Renato Talamini 2, Carlotta Galeone 1, Eva Negri 1, Silvia Franceschi 3, Luigino Dal Maso 2, Maurizio Montella 4, Ettore Conti 5, Carlo La Vecchia 1 6 1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy 2Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy 3International Agency for Research on Cancer, Lyon, France 4Servizio di Epidemiologia, Istituto Tumori Fondazione Pascale, Naples, Italy 5Servizio Integrato di Epidemiologia e Sistemi Informativi (SINTESI), Rome, Italy 6Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy email: Claudio Pelucchi (pelucchi@marionegri.it) *Correspondence to Claudio Pelucchi, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62-20157 Milano, Italy Fax: +39-02-33200231 Dr. Conti is deceased. Funded by: Italian Association for Cancer Research Italian League against Cancer Abstract Dietary fibre has been reported to protect from several neoplasms, but the issue remains controversial. No previous study considered in depth the topic of fibres and prostate cancer. A multicentre case-control study was conducted in Italy from 1991 to 2002, including 1,294 men with incident, histologically confirmed prostate cancer and 1,451 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. Compared to the lowest quintile, the OR of prostate cancer for the highest quintile of total fibre intake was 0.93 (95% CI 0.71-1.22). The risk was inversely related with soluble fibre (OR = 0.89, 95% CI 0.78-1.02, for a difference between 80th and 20th percentile), cellulose (OR = 0.88, 95% CI 0.78-1.01) and vegetable fibre (OR = 0.82, 95% CI 0.73-0.93). These relationships were consistent across strata of age, family history of prostate cancer, body mass index and education. Vegetable fibres appear, therefore, to have a favourable association with prostate cancer risk. International Journal of Cancer Volume 109, Issue 2 , Pages 278 - 280 Euro J Ca Prev, 10/03 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.