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ABSTRACT: Fat consumption and breast cancer: preliminary results
from the E3N-Epic cohort
[11/19/2001; Bulletin du Cancer]
Recent reviews have concluded that a high consumption of total,
saturated or animal, fat could possibly increase the risk of
breast cancer. However these results are highly dependent on
the type of study; indeed, most of the prospective studies do
not support this association.
In this paper, we investigated the
relationship between fat consumption and breast cancer risk in
the E3N-Epic cohort, the French component of the European
Prospective Investigation into Cancer and Nutrition.
Assessment
of fat consumption was based on daily intakes of food items and
nutrients using a food-frequency questionnaire. Relative risk
(RR) estimates were calculated using Cox's proportional hazards
model.
After an average of 3.4 years of follow-up, 838 cases of
incident breast cancer were recorded in a study population of
65,879 women. The mean caloric intake was 2,073 kcal (SD 540),
with 37% of calories coming from fat intake. Milk products and
vegetable oils were the main sources of fat in the diet.
We found
a small positive association between fat intake and breast
cancer risk. Compared with the lowest, women in the highest
quartile of fat intake had a 37% higher risk of breast cancer
(RR 1.37, CI95% = 0.99-1.89).
There was no detectable association
between fatty acids or food items contributing to fat intake
and breast cancer risk.
These analyses suggest there is a
need for longer follow-up time to increase statistical power
and confirm these tendencies.
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