ABSTRACT: Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTP-gammaamma) mRNA expression by estrogenically active agents Background: Protein tyrosine phosphatase g (PTP-gamma) has been implicated as a tumor suppressor gene in kidney and lung cancers. Our previous results indicate that estradiol-17-beta (E_2)-induced suppression of PTP-gamma may play a role in mammary tumorigenesis. Zeranol (Z), a nonsteroidal growth promoter with estrogenic activity that is used by the US meat industry, induces estrogenic responses in primary cultured breast cells and breast cancer cell lines. Conclusions: The results indicate that both E_2 and Z regulate PTP-gamma expression in human breast and that epithelial-stromal cells interaction is important in the regulation of PTP-gamma expression by estrogenically active agents. [12/26/2001; Breast Cancer Research and Treatment] Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.