Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma M F Ji1, D K Wang1, Y L Yu1, Y Q Guo1, J S Liang1, W M Cheng1, Y S Zong2, K H Chan3, S P Ng3, W I Wei4, D T T Chua5, J S T Sham5 and M H Ng3 1Cancer Research Institute of Zhongshan City, Zhongshan City, PRC 2Department of Pathology, Sun Yat Sen Medical College, Sun Yat Sen University, Guangzhou, PRC 3Department of Microbiology, Hong Kong SAR, PRC 4Department of Surgery, Hong Kong SAR, PRC 5Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PRC Correspondence to: Professor MH Ng, E-mail: hrmmnmh@hku.hk We have monitored Epstein-Barr virus (EBV) IgA antibody levels of 39 nasopharyngeal carcinoma (NPC) cases for up to 15 years before clinical onset of NPC, and assessed preclinical serologic status of another 68 cases. Our results identify a serologic window preceding diagnosis when antibody levels are raised and sustained. This window can persist for as long as 10 years, with a mean duration estimated to as 37±28 months. Ninety-seven of these 107 NPC cases exhibited such a window. Cases that did not may reflect individual antibody response to EBV. Serologic screening at enrollment identified those cases who had already entered the window and became clinically manifested earlier (median=28 months) than those who entered the window after enrollment (median=90 months). The former account for 19 of 21 cases diagnosed within 2 years of screening. Nasopharyngeal carcinoma risk levels among seropositive subjects were also highest during this period. Both prediction rates and risk levels declined thereafter; cases detected at later times were composed of increasing proportions of individuals who entered the serological window after screening. Our findings establish EBV antibody as an early marker of NPC and suggest that repeated screening to monitor cases as they enter this window has considerable predictive value, with practical consequences for cancer treatment. British Journal of Cancer (2007) 96, 623-630. doi:10.1038/sj.bjc.6603609 www.bjcancer.com Published online 6 February 2007 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.