#B149 Dietary Phytochemical Intake and Prostate Cancer Risk. Susan E. McCann,1 Christine B. Ambrosone,1 Kirsten B. Moysich,1 Jo L. Freudenheim,2 James R. Marshall.1 Roswell Park Cancer Institute,1 Buffalo, NY, Univ. at Buffalo,2 Buffalo, NY. A number of epidemiologic studies have suggested that diet may affect the etiology of prostate cancer, but few studies have emphasized the impact of phytochemical intakes on this cancer. We conducted a case-control study of diet and prostate cancer in western New York involving 433 primary, histologically-confirmed prostate cancer cases and 538 population-based controls, frequency matched to cases on age and county of residence. Diet was assessed with a detailed food frequency questionnaire. We calculated daily intakes of beta-sitosterol, campesterol, stigmasterol, total phytosterols, total lignan precursors, quercetin and kaempferol based on published food composition data. Odds ratios (OR) and 95% confidence intervals (CI) describing the association of prostate cancer risk with each phytochemical were estimated with unconditional logistic regression adjusting for age, education, smoking status, body mass index, and energy intake. Compared to men in the lowest quartile of intake, reduced risks were observed for men in the highest quartile of intake of total lignan precursors (OR 0.67, 95% CI 0.46-0.97), and the flavonoids quercetin (OR 0.55, 95% CI 0.38-0.82) and kaempferol (OR 0.72, 95% CI 0.50-1.03). We observed no association between prostate cancer risk and intakes of beta-sitosterol, campesterol, stigmasterol, or total phytosterols. These results, indicating a protective association between prostate cancer risk and phytoestrogen and flavonoid intakes, support the hypothesis that a plant-based diet may be important in reducing risks of hormone-related neoplasms. Frontiers in Cancer Prevention Research, 2003 AACR Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.