DIETARY FACTORS IN HUMAN COLORECTAL CANCER Martin Lipkin,1 Bandaru Reddy,2 Harold Newmark,3 and Sergio A. Lamprecht1, 1Strang Cancer Prevention Center and The New York Hospital-Cornell Medical Center, New York, New York, 2The American Health Foundation, Valhalla, New York, 3Rutgers University,Laboratory for Cancer Research, Piscataway, New Jersey; e-mail: lipkin@rockvax.rockefeller.edu Colorectal cancer is a significant cause of mortality in Western societies. The progression of the disease from normal colonic epithelium to the acquisition of the malignant phenotype is accompanied by numerous genetic and epigenetic alterations. Compelling experimental and epidemiological evidence indicates that diet and nutrition are key factors in the modulation of colorectal cancer. A salient case in point is the recent observation that a dietary regimen based on a Western-style diet provokes in the rodent colon the appearance of preneoplastic lesions in the absence of any genotoxic insult. This review mainly describes dietary factors that inhibit the development and progression of colorectal cancer. Much is unknown about the precise mechanisms of action of chemically disparate nutrients and how they interfere with the development and progression of this disease. Current knowledge about this important issue is summarized. We believe that continuing scrutiny and precise assessment of the benefits (and potential risks) of nutrients in the treatment and prevention of colorectal cancer will prove significant to controlling this devastating disease. Annu. Rev. Nutr. 1999. 19:17-40. |
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| Euro Prospective Study: Meat, Fish, Colorectal Ca Risk JNCI, 6/15/05 | | | Eat Less & Eat Healthier (+ Exercise) Experimental Biology, 2002 Conference presentation | ||
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| Fruit/Veg & Risk of Colorectal Ca (in BCA Cohort) Am J Clin Nutr, 5/02 | | | Vegs, Tea, Soy on N-Nitrosation Nutr Cancer, 9/02 | ||
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| Dietary Patterns & Risk of Colon Ca Arch Intern Med, 2/03 | | | Refined Cereal/High-Fat Animal Products RISK Nutr & Cancer, 3/03 | ||
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| Food as Risk Factors Colon Adenomas (France) Nutr & Cancer, 2002 | | | Egg Consumption & Mortality:Colon/Rectal Ca Nutr & Cancer, 12/03 | ||
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| Vegetarians and Colorectal Cancer Incidence Br J Cancer, 1/04 | | | Omega3 Polysaturated Oil & Colon Ca Prvntn Clin Nutr, 4/04 | ||
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| Antitumor Effects: Combo Tea Oncol Rep, 3/05 | | | Nutritional Habits from Ulcerative Colitis - CA Development Br J Nutr, 1/06 | ||
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| Functional food ingredients against colorectal cancer - 'Omics' Abstract #3162 Proc Amer Assoc Cancer Res, March 2004 | |||||
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