#B147 Dietary B Vitamins and the Risk of Lymphoid Cancers in Male Smokers. Unhee Lim,1 Rachael Stolzenberg-Solomon,1 Jarmo Virtamo,2 Pirjo Pietinen,2 Philip R. Taylor,1 Demetrius Albanes.1 National Cancer Inst.,1 Rockville, MD, National Public Health Institute,2 Helsinki, Finland. Genetic polymorphisms in folate-regulating enzymes have been suggested to alter the risk of lymphoid cancers through their impact on one-carbon metabolism and DNA stability. We prospectively examined the association of dietary factors of one-carbon metabolism with lymphoid cancers on the 27,111 healthy male smokers who completed dietary questionnaires in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Cohort. During up to 13 years of follow-up (1985 − 1997), 147 non-Hodgkin’s lymphoma (NHL) and 42 lymphocytic leukemia (LL) cases were diagnosed (N = 189). Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI). The adjusted RR for combined lymphoid cancers comparing the highest to the lowest quintiles of energy-adjusted dietary vitamin B12 intake was 0.56 (95% CI, 0.36-0.88; p − trend = 0.012), with a stronger inverse association primarily for NHL (RR = 0.45; 95% CI, 0.27 − 0.76; p − trend = 0.016). There was no significant association between folate (RR = 0.92; 95% CI, 0.58 − 1.44) or vitamin B6 (RR = 0.88; 95% CI, 0.57 − 1.36) and lymphoid cancers comparing the highest to the lowest quintiles. Our results support the hypothesis that dietary B12 may be inversely associated with NHL. Frontiers in Cancer Prevention Research, 2003 AACR Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.