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DCIS w/Microinvasion-Significance

ABSTRACT: Breast ductal carcinoma in situ with microinvasion: A definition supported by a long-term study of 1248 serially sectioned ductal carcinomas

BACKGROUND: The significance of microinvasion is still debated and clinical management is controversial. The authors defined ductal carcinoma in situ with microinvasion (DCIS-MI) as DCIS with infiltration of the periductal stroma by a few tumor cells, singly (type 1) or in clusters (type 2). With this definition, the authors attempted to evaluate the clinical significance of microinvasion.

CONCLUSIONS: The authors' results suggest there are two types of DCIS-MI: 1) type 1 that behaves like DCIS and should be managed as such; 2) type 2 that is less pejorative than IDC-DCIS but is more so than type 1.

[04/16/2002; Cancer Online)

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