The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful1 M. Emília Juan, M. Pilar Vinardell and Joana M. Planas2 Departament de Fisiologia–Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain 2To whom correspondence and reprint requests should be addressed. E-mail: jplanas@farmacia.far.ub.es. trans-3,5,4'-Trihydroxystilbene (trans-resveratrol) is a phytochemical present in peanuts, grapes and wine with beneficial effects such as protection against cardiovascular disease and cancer prevention. The purpose of this study was to evaluate whether high doses of trans-resveratrol have harmful effects on Sprague-Dawley rats. trans-Resveratrol was administered orally to male rats for 28 d at a dose of 20 mg/(kg · d), 1000 times the amount consumed by a 70-kg person taking 1.4 g of trans-resveratrol/d. Body weight, and food and water consumption did not differ between rats treated with trans-resveratrol and the control group. Hematologic and biochemical variables were not affected by the treatment. Histopathologic examination of the organs obtained at autopsy did not reveal any alterations. These results support the view that repeated consumption of trans-resveratrol at 20 mg/(kg · d) does not adversely affect the variables tested in rats. © 2002 The American Society for Nutritional Sciences J. Nutr. 132:257-260, 2002 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.