Colorectal Cancer

Colorectal Cancer

Colorectal cancer incidence seems to be increased by diets high in saturated fats and low in fruits and vegetables, as well as by sedentary lifestyles and obesity.44 After a diagnosis of colorectal cancer, the most important determinants of survival seem to be adherence to the full treatment regimen (especially if chemotherapy is recommended) and colonoscopic surveillance to look for new lesions.

Selenium

Selenium supplementation was associated with reduced risk of colorectal cancer diagnosis in a trial designed to affect skin cancer incidence,171 but whether selenium might be beneficial after colorectal cancer diagnosis is un-certain. If selenium is taken, it should be as a brewer’s yeast preparation in doses no higher than 200 mcg per day.

High Dietary Fiber

Although high-fiber diets have been recommended to reduce colorectal cancer risk, there is more evidence of a benefit with respect to general bowel function (e.g., preventing constipation) than for colorectal cancer risk reduction. Colorectal cancer survivors can have residual problems with bowel function (both diarrhea and constipation) after treatment.

Survivors should be advised to maintain a reasonable weight, eat a well-balanced diet, and participate in regular physical activity after treatment. Colorectal cancer survivors with chronic bowel problems should be referred to a qualified nutritionist to modify diet and activity.

As colorectal cancers arise from adenomatous polyps, the prevention of polyp growth has been a focus of considerable clinical research. To date, trials have failed to show benefits over a three-year period from taking antioxidant vitamins, fiber supplements, or modest dietary changes with respect to preventing new polyp growth.105,187-189 There was a modest benefit from calcium supplements, however, in terms of reducing polyp growth. Trials testing the effects of aspirin and folic acid are underway.105,190

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