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ABSTRACT: Chemotherapy Causes Rapid Bone Loss in Women: Study
[07/13/2001; Journal of Clinical Oncology]
WASHINGTON (Reuters) - Chemotherapy given to women
with breast cancer causes their bone density to decline
at a faster rate than previously known, increasing the risk of
osteoporosis, researchers said on Thursday.
Scientists led by
Dr. Charles Shapiro at Ohio State University said they were surprised
to find that 35 pre-menopausal women treated with chemotherapy
experienced up to an 8% loss in bone density after 12 months
of treatment. The median age of the women was 42.
The bone loss
in the patients treated with chemotherapy was so significant,
the researchers said, that the study was halted to allow the
women to seek care from their primary physician.
``We were surprised
that (bone loss) occurred so early because other studies had
begun to evaluate patients at 12 months'' after chemotherapy
commenced, Shapiro told Reuters. ``An independent committee met,
and they concluded that these 35 women have lost so much bone,
8%, in the spine that it was unethical in view of that to treat
them with placebo,'' he said.
The study appears in the Journal
of Clinical Oncology.
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