Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in mice G. Chamorro-Cevallosa, , , L. Garduño-Sicilianoa, B.L. Barrónb, E. Madrigal-Bujaidarc, D.E. Cruz-Vegad and N. Pagese aDepartamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Carpio y Plan de Ayala S/N, 11340 México D.F., México bDepartamento de Microbiología y, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Carpio y Plan de Ayala S/N, 11340 México D.F., México cDepartamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Carpio y Plan de Ayala S/N, 11340 México D.F., México dDivisión de Biología Celular y Molecular. Centro de Investigación Biomédica del Noreste. Instituto Mexicano del Seguro Social, 2 de Abril y San Luis Potosí, Colonia Independencia, CP 64720, Monterrey, N.L., México eToxicology Laboratory, Faculty of Pharmacy, Illkirch, France Received 4 May 2007; accepted 24 August 2007. Available online 5 September 2007. Abstract The aim of this study was to investigate the antimutagenic effects of Spirulina (SP) on male and female mice by the dominant lethal test using cyclophosphamide (CP) as a mutagen. Animals of both sex were given SP orally at 0, 200, 400 or 800 mg/kg body weight (b.w.) for 2 weeks prior to starting the CP treatment. CP was i.p. injected daily for 5 days at 40 mg/kg b.w. For the male-dominant lethal test, each male was caged with untreated females per week for 3 weeks. For the female-dominant lethal test the above doses and schedule treatments were used and treated females were caged for one week with untreated males (1–2). On days 13–15 after breeding was |started all the females were evaluated for incidence of pregnancy, total corpora lutea, total implants and pre- and post-implant losses. In the male-dominant lethal test, the CP induced pre- and post-implant losses in untreated females were inhibited at all SP doses. In the female-dominant lethal test only post-implantation losses were prevented at the same doses. Semen examination of a separate group of mice showed that SP improved its quality. Our results illustrate protective effects of SP in relation to CP-induced genetic damage to germ cells. Abbreviations: CP, cyclophosphamide; SP, Spirulina Corresponding author. Tel./fax: +5255 5396 8929. Food and Chemical Toxicology Volume 46, Issue 2, February 2008, Pages 567-574 doi:10.1016/j.fct.2007.08.039 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.