Epidemiology Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trial Susan Steck-Scott 1 *, Michele R. Forman 2, Anne Sowell 3, Craig B. Borkowf 2, Paul S. Albert 4, Martha Slattery 5, Brenda Brewer 6, Bette Caan 7, Electra Paskett 8, Frank Iber 9, Walt Kikendall 10, James Marshall 11, Moshe Shike 12, Joel Weissfeld 13, Kirk Snyder 14, Arthur Schatzkin 15, Elaine Lanza 2, The Polyp Prevention Trial Study Group 16 1Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 2Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 3Centers for Disease Control, Atlanta, GA, USA 4Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA 5University of Utah, Salt Lake City, UT, USA 6Westat, Rockville, MD, USA 7Kaiser Foundation Research Institute, Oakland, CA, USA 8Wake Forest University School of Medicine, Winston-Salem, NC, USA 9Edward Hines, Jr., Hospital, Veterans Affairs Medical Center, Hines, IL, USA 10Walter Reed Army Medical Center, Washington, DC, USA 11Roswell Park Cancer Institute, Buffalo, NY, USA 12Memorial Sloan-Kettering Cancer Center, New York, NY, USA 13University of Pittsburgh, Pittsburgh, PA USA 14Information Management Services, Inc., Rockville, MD, USA 15Nutritional Epidemiology Branch, Division of Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA 16Other members of the Polyp Prevention Trial Study Group are listed in the Appendix email: Susan Steck-Scott (susan_scott@unc.edu) *Correspondence to Susan Steck-Scott, CB 7461, Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Fax: +919-966-7216 Abstract One trial reported beta-carotene supplementation was protective of adenomatous polyp recurrence in nonsmokers. We now examine the relation of serum and dietary carotenoids and vitamin A to adenomatous polyp recurrence in a subcohort of 834 participants in a low fat, high fiber, high fruit and vegetable dietary intervention, the Polyp Prevention Trial. Multivariate odds ratio (OR) and 95% confidence intervals (CI) of polyp recurrence were obtained using baseline or the average (first 3 years of the trial) carotenoid and vitamin A values after adjustment for covariates. Compared to the lowest quartile of baseline alpha-carotene concentrations, the OR of multiple polyp recurrence for the highest quartile was 0.55 (95% CI = 0.30-0.99) and the OR of right-sided recurrence was 0.60 (95% CI = 0.37-0.95). Baseline dietary intakes of alpha-carotene and vitamin A from food with/without supplements were inversely associated with any recurrence (pfor linear trend = 0.03- alpha-carotene; p = 0.004 and p = 0.007 -intakes of vitamin A). Compared to the lowest quartile of averaged beta-carotene concentrations, the OR of multiple adenomas for the highest quartile was 0.40 (95% CI = 0.22-0.75) with an inverse trend (p = 0.02). The risk was inversely related to averaged: alpha-carotene concentrations and right-sided polyps; alpha-carotene intake and recurrence of any, multiple and right-sided polyps; beta-carotene intake and multiple adenoma recurrence; vitamin A from food (with supplements) and each adverse endpoint. Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. International Journal of Cancer Volume 112, Issue 2 , Pages 295 - 305 Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.