The Management of Cancer-Related Fatigue After Chemotherapy with Acupuncture and Acupressure: a Randomised Controlled Trial. Molassiotis A, Sylt P, Diggins H. University of Manchester, School of Nursing, Midwifery & Social Work, Coupland III, Coupland Street, Manchester M13 9PL, UK. alex.molassiotis@manchester.ac.uk Background: Cancer-related fatigue after chemotherapy is a difficult symptom to manage in practice and the most disruptive symptom in patients' lives. Acupuncture is a popular complementary therapy among cancer patients and some evidence exists that it could potentially alleviate fatigue by stimulating 'energy' points in the body. Hence, this study was carried out to assess the effects of acupuncture and acupressure in managing cancer-related fatigue and the feasibility of running a randomised trial with these two complementary therapies in preparation for a large trial. Methods: This study was a randomised controlled trial. Forty-seven patients with cancer who experienced moderate to severe fatigue were randomised either to an acupuncture group (n=15), an acupressure group (n=16) or a sham acupressure group (n=16). The acupuncture group received six 20-min sessions over 2 weeks, while the patients in the two acupressure groups were taught to massage/press the points and did so daily thereafter for 2 weeks on their own. Patients completed the Multidimensional Fatigue Inventory before randomisation, at the end of the 2-week intervention and again about 2 weeks after the end of the intervention. Results: Significant improvements were found with regards to General fatigue (P<0.001), Physical fatigue (P=0.016), Activity (p=0.004) and Motivation (P=0.024). At the end of the intervention, there was a 36% improvement in fatigue levels in the acupuncture group, while the acupressure group improved by 19% and the sham acupressure by 0.6%. Improvements were observed even 2 weeks after treatments, although they were lower (22%, 15%, 7%, respectively). Acupuncture was a more effective method than acupressure or sham acupressure. Subjects needed a longer treatment period to have more sustained results. The trial was methodologically feasible. Conclusion: Acupuncture shows great potential in the management of cancer-related fatigue. As a randomised trial with acupuncture is feasible and preliminary data shows significant improvements, it should be tested further using a large sample and a multicentre design. Comment by Joel Evans, MD: This article comes ten years after the National Institute of Health stated that acupuncture showed promising results for the treatment of chemotherapy associated nausea and vomiting (National Institutes of Health Consensus Panel. Acupuncture: National Institutes of Health Consensus Development Conference Statement). As all practitioners who care for patients undergoing cancer treatment are aware, fatigue is a common side effect. I have had great results referring these patients for acupuncture, and here is a research paper that demonstrates impressive results. I offer acupuncture to all patients undergoing cancer treatment to both prevent and treat side effects, and this paper provides additional support for this practice. Complement Ther Med. 2007 Dec;15(4):228-37. Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.