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ABSTRACT: Breastfeeding and Reduced Risk of Breast Cancer in an
Icelandic Cohort Study
[06/27/2001; American Journal of Epidemiology]
Case-control studies on the association between breastfeeding
and the subsequent risk of breast cancer have given inconsistent
results.
To date, only two cohort studies have been reported
on this subject. The present nested case-control study uses data
from an Icelandic cohort of 80,219 women visiting a Cancer Detection
Clinic that offers population-based cervical and breast cancer
screening, in the years 1979-1995.
The 993 parous cases
were aged 26-90 years at diagnosis, with 9,729 parous controls
individually matched on birth year, vital status at case diagnosis,
and age when giving information on several potential risk factors
for breast cancer.
Using conditional logistic regression and
confining the analysis to the 84 cases who were <40 years
at diagnosis, an inverse association was evident between total
duration of breastfeeding and breast cancer, with the adjusted
odds ratio = 0.77 per 6 months' increase in duration of breastfeeding
(95% confidence interval: 0.59, 1.00), whereas for the remainder
of the women, a much weaker trend was observed. Ever lactating
was associated with decreased risk, with the adjusted odds ratio
= 0.33 (95% confidence interval: 0.19 , 0.56) for women diagnosed
at all ages.
This is the first cohort study to indicate a negative
association between breastfeeding and breast cancer.
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 Int J Cancer, 4/03

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 JNCI, 7/04

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