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Fresh Evidence Points To Marine Bacteria As A Source Of Anti-Cancer
Drug
[10/25/2001; ScienceDaily]
Researchers at Scripps Institution of Oceanography at the University
of California, San Diego (UCSD), have produced evidence that
bacteria living inside a small marine animal may be the source
of a new drug compound being developed to fight cancer.
The marine invertebrate Bugula neritina, a brown bryozoan animal
with stringy tufts that look like algae, appears unremarkable
and similar to a variety of moss-like sea creatures.
In fact,
bryozoans are widely known by boat operators, who consider them
ordinary fouling organisms and often scrape them off their vessels'
hulls.
But their potential may be far from ordinary. Scientists previously
discovered Bugula neritina to be the source of bryostatins, a
family of chemical compounds currently being studied for their
ability to treat a variety of cancers.
The anti-cancer drug Bryostatin
1 can be extracted from colonies of Bugula neritina.
The new study provides evidence that bacteria that live inside
Bugula neritina, and are passed in larvae from one generation
to the next, are the likely source of the anti-cancer compound.
"This paper presents a whole series of experiments from a variety
of different directions that provide evidence that this bacteria
may indeed be the agent for producing the drug," said Margo Haygood,
the senior author of the paper appearing in this month's issue
of Applied and Environmental Microbiology.
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 Institute of Oceanography
5/02

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