3/19/07 Here is a link to some informational videos about clinical trials. These videos are intended to help patients and caregivers learn about trials that are available and where they can be accessed. They are produced by the Eastern Cooperative Oncology Group,one of the first cooperative groups launched to perform multi-center cancer clinical trials. http://www.ecog.org/general/videos/ We also have a link to CenterWatch, as well as the main government cancer trial website, both of which offer information on clinical trials. Also, please check out the specific health and natural product studies we show below. The Annie Appleseed Project has asked that trials of natural substances be placed on any link we connect to, as well as the many conventional trials of chemotherapy, radiation and surgery. (Currently 8/01, studies listed are all NCI approved). That is why specific other trials are shown below. As of this writing in December 2000, FDA, the Food and Drug Administration requires all trials to be listed by the goverment. Some pharmaceutical companies have resisted doing this. But participation is growing. At some point in the near future, ALL trials will be listed. Phase I trials are conducted to test safety levels. People who participate (all trial participation is voluntary)are given various doses of the drug being tested. (Small numbers of people involved) Phase II trials test efficacy to see if the drug is effective against whatever cancer it is being used for. (Relatively small number of people involved). Phase III trials are usually larger scale with many people trying the drug under question, sometimes at two different strengths, against another already accepted therapy, or in some cases, placebo. These separate treatment sections are called arms. There have been trials of vitamins or "analogues" (synthetic forms)using human subjects. Most of the studies in the Relevant Studies section of this website, were done in animals or cell culture. BUT NOW IS THE TIME TO PUSH FOR HUMAN TRIALS. We need to know how to use natural, nontoxic substances for people with cancer. You can help by contacting FDA or NCI (National Cancer Institute) and telling them. The Center for Complementary/Alternative Medicine is now part of the National Institutes of Health. It conducts studies of natural substances, but its mandate is all diseases. Not enough funding has been done for cancer studies. Contact them and ask for more studies. In their first year of operation, the VAST majority of callers wanted information on cancer therapies. And we have been told that the trend continues. LINK, CAM trials can be found by type of cancer or all cancer as on this page LINK to Natl Inst of Health/Natl Library of Med site UCSF study, 11/06 www.lef.org January 2008 Posted 1/06 LINK to informational video from patient organization site 1/06 Press Release, May 14, 2007 NCI Cancer Bulletin, September 2007 From the National Cancer Institute Smoking Cessation:Cancer Survivors Chemoprevention Selenium for Non-Small Cell Lung Ca 8/05 LINK 12/05 "The purpose of study is to learn more about how you use the Internet for activities related to breast cancer & to find out your views about online breast cancer info". UCLA Study, 5/04 Ages 45-65 West Los Angeles, CA LINK to site to find trials of conventional therapies Call Janelle Maxwell (650)498-7740, California UCLA-based study, 2/04 January 2001, Harris Interactive Poll Risks & Benefits of Clinical Trials Often Misunderstood Clinical Trials: Are they a Good Buy? Study Risks Not Disclosed on Web Sites Cancer Patients' Needs/Concerns, Key to Improved Commun Most Don't Ask Key Questions Before Enrolling Link to clinical trial over the Internet for Kava & Valerian LINK Info on centers and universities, cooperative groups Patient support-drugs and clinical trials, FDA Adjuvant Therapy for Stage II or III Phase III Trial Protocol No. MU-699-501 Article on Drug that acts on Enzymes Various studies, 3/01 Revival Soy-Breast Cancer Tissue Proliferation in Vivo Urinary Isoflavone Profile Excretion at Hollings Cancer Institute Univ of SC You have to contact the Maitake Co. for the information (LINK) Sponsored by Nat'l Center for Complementary and Alternative Medicine (NIH) ACRIN study, 1/04 8/01 Univ of Michigan LINK for Studies on Women's Health Information, contacts and a link Chinese Herbal Medicine After Bca: Hot Flashes Randomized Study of Tai Chi Adult Ca Survivors Clinical Cancer Letter, 10/01-contact information Phase II Trial at Memorial Sloan Kettering Ask your physician to check out www.ctsu.org Cleveland Clinic Study needs volunteers, 2003 Phase I Surrogate Biomarker Trial: Perillyl Alcohol/Breast NIH announcement From Diana Dyer, author, cancer dietician, advocate Synthetic version of natural therapy Oregon Health & Science University and other centers Some possible trials of natural therapies or close to it. Acupuncture for Menopausal Symptoms (Breast Ca) Yondelis (ET-743, Naturally-occurring Marine Organism Massage Therapy/Fatigue During Chemotherapy Calcium/Vit D for Colon Cancer Prevention Study CAM as Lifestyle Effect: on BCa and Surviving Hypnosis for Hot Flashes in BCa Survivors Diet & Exercise Research Study Milk Thistle Extract for Chemotherapy-Induced Liver Toxicity Explanations/discussions/strategies Read an advocate's perspective on studies and testing An Advocate's Perspective Managing Conflicts of Interest in Conduct of Clinical Trials WHO Experts New Rules/Clinical Res Nontoxicity Endpoints Phase I: Targeted Non-cytotoxic Agents Supporting 'Double-Blind Clinical Trials Selective Reporting Biases: Cancer Prognostic Factor Studies Very Critical of Clinical Trials-Part I Patient-Centered Approach: Participatory Action Res Clin Trials The Trust Factor: Editorial Int'l Network & Developing Nations Unethical:Underpowered Trials Premature Termination/Clinical Trials (excerpts) Media's & Human Subject Participation Patient Selection:Applicability of Results Instl Review Bds:Advocate Perspective Clinical res/Exp treat 11/3/97 Pharmas Dictate What/How Research Published Public Attitudes on Participation Are Large Clinical Trials Ethical Coalitn of Natl Cancer Coop Groups Improved Design for Clinical Trials & Multiple Agents Evaluation of Randomised Controlled Trials Placebo Research "Why Most Published Research Findings are False" Part I Evidence-based Movement Exclusionary - Paper states Chemopreventive Agent for High Risk Women Clinical Trial: Ovarian Ca Monoclonal Antibody Plymouth Michigan area 3/03 LINK to research in US/UK & private groups LINK to joint initiative of US/UK Cancer Research Funding Organizations 2/04 National Cancer Institute Study Washington, DC, VA, MD areas posted 2/29/04 Many cancer centers around the country LINK to Trial Memorial Sloan Kettering, NYC 8/04 Posted 11/09/04 Trial stopped 4/06/05 LINK to site with information on trials LINK to "a single entry allowing you to search for comprehensive information on on-going clinical trials (registry) or results of completed trials (database) conducted by the innovative pharmaceutical industry". Posted 2/06 Posted June 2006, Open Study Ann Fonfa's Correspondence with Dr. Lund Remember we are NOT Doctors and have NO medical training. This site is like an Encylopedia - there are many pages, many links on many topics. Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.